A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers
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This pilot study evaluated whether endometrial biopsy or full curettage was more effective in diagnosing endometriosis through the detection of endometrial nerve fibers.
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Abstract
ObjectiveThe purpose of this study was to evaluate endometrial biopsy and curettage in detecting small nerve fibers in eutopic endometrium for diagnosis of endometriosis.Study designEndometrial biopsies with precise, consistent technique and curettings were taken from 37 women (20 with endometriosis and 17 without endometriosis). Sensitivity, specificity, and positive and negative predictive value were formally calculated. Endometrial nerve fibers were immunohistochemically detected using the pan-neuronal marker PGP9.5.ResultsSmall nerve fibers were detected in all endometrial biopsies and curettings from all 20 women with endometriosis, but were not detected in endometrium taken from 17 women without endometriosis. Mean (+/-SD) nerve fiber density in the endometrial biopsies was 26.8 per mm(2) +/- 55.9 (range, 1.6-125) and for curettings was 21.6 per mm(2) +/- 33.1 (range, 0.8-250), with 100% specificity, sensitivity, and positive and negative predictive value.ConclusionCareful endometrial biopsy combined with immunohistochemical staining for nerve fibers may be a reliable means of diagnosing or excluding endometriosis.
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References (8)
- Changing trends in the diagnosis of endometriosis: A comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility via openalex
- Diagnostic delay in women with pain and endometriosis via openalex
- Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis via openalex
- High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis via openalex
- Nerve fibres in peritoneal endometriosis via openalex
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996 via openalex
- Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women via openalex
- W2064553736 via openalex
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- Mysteries of endometriosis pain: Chien‐Tien Hsu Memorial Lecture 2009 2010
- Endometriose und Nervenfasern 2010
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- Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids 2009
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