A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers
Non-randomised trial
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⤵ 59 in-corpus citations
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This pilot study evaluated whether endometrial biopsy or full curettage was more effective in diagnosing endometriosis through the detection of endometrial nerve fibers.
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Abstract
OBJECTIVE: The purpose of this study was to evaluate endometrial biopsy and curettage in detecting small nerve fibers in eutopic endometrium for diagnosis of endometriosis.
STUDY DESIGN: Endometrial biopsies with precise, consistent technique and curettings were taken from 37 women (20 with endometriosis and 17 without endometriosis). Sensitivity, specificity, and positive and negative predictive value were formally calculated. Endometrial nerve fibers were immunohistochemically detected using the pan-neuronal marker PGP9.5.
RESULTS: Small nerve fibers were detected in all endometrial biopsies and curettings from all 20 women with endometriosis, but were not detected in endometrium taken from 17 women without endometriosis. Mean (+/-SD) nerve fiber density in the endometrial biopsies was 26.8 per mm(2) +/- 55.9 (range, 1.6-125) and for curettings was 21.6 per mm(2) +/- 33.1 (range, 0.8-250), with 100% specificity, sensitivity, and positive and negative predictive value.
CONCLUSION: Careful endometrial biopsy combined with immunohistochemical staining for nerve fibers may be a reliable means of diagnosing or excluding endometriosis.
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- The Clinical Usefulness of Endometrial Biopsy for the Diagnosis of Endometriosis in the Work up of Women with Infertility 2016
- Preoperative assessment and diagnosis of endometriosis: are we any closer? 2015
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- Semi-invasive Diagnosis of Endometriosis Doctoral Thesis 2010
- Protein kinase inhibitors can control the progression of endometriosis in vitro and in vivo 2010
- [Neurotrophins and pain in endometriosis] 2010
- Mysteries of endometriosis pain: Chien-Tien Hsu Memorial Lecture 2009 2010
- Endometriose und Nervenfasern 2010
- Diagnosis of endometrial nerve fibers in women with endometriosis 2010
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- Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine 2009
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