Neurotrophin Expression Is Not Affected in Uteri of Women with Adenomyosis

Maria Luisa Barcena, Maria Luisa Barcena de Arellano, Melanie Franziska Wagner, Jeannette Oldeweme, Julia Arnold, Julia T. Arnold, Andreas Ebert, Andreas D. Ebert, Achim Schneider, Sylvia Mechsner
Journal of molecular neuroscience : MN · 2012 · vol. 47(3) , pp. 495–504 · doi:10.1007/s12031-012-9757-x · PMID:22454143 · W1972238402
article OA: closed CC0 ⤵ 12 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study found no significant differences in neurotrophin or nerve fiber expression in the uteri of women with adenomyosis compared to controls, though a trend of decreased myometrial nerve fibers was observed.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective clinical immunohistochemical study examined uterine neurotrophin expression and nerve fibre markers in hysterectomy specimens from 40 women with histologically proven adenomyosis and 20 controls without adenomyosis or endometriosis, assessing NGF, NT-3, TrkA, p75NTR, and the nerve markers S100 (myelinated fibres) and PGP9.5 (intact fibres). The study found no significant differences in NGF, NT-3, or p75NTR expression between adenomyosis and controls in either the myometrium or endometrium, and nerve fibre density based on S100, PGP9.5, and p75NTR did not significantly differ (though it was tendentially decreased in adenomyosis versus a nonporous control group). A caveat noted in the abstract is the “tendential” reduction without statistically significant differences for nerve density. This paper is centrally about endometriosis and/or adenomyosis—specifically adenomyosis—because it directly tests whether uterine neurotrophin expression and innervation are altered in adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Nerve Growth Factor Neurotrophin 3 Adenomyosis Adult Female Humans Middle Aged Nerve Growth Factor Nerve Tissue Proteins Nerve Tissue Proteins Neurotrophin 3 Receptors, Nerve Growth Factor Receptors, Nerve Growth Factor Receptor, trkA Receptor, trkA S100 Proteins S100 Proteins Ubiquitin Thiolesterase

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