Uterine innervation in adenomyosis

M.J. Quinn, M Quinn
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2007 · vol. 27(3) , pp. 287–291 · doi:10.1080/01443610701213976 · PMID:17464814 · W2007604118
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This study found that uteri with adenomyosis exhibit a loss of nerve fibers at the endometrial-myometrial interface and absence of nerve fibers within the adenomyosis tissue itself.

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Abstract

This study describes the innervation of the uterus with a histopathological diagnosis of adenomyosis in a retrospective survey of two groups of uteri. Group 1 consisted of 17 histologically-normal, parous uteri and eight nulliparous uteri. Group 2 consisted of 23 parous uteri with the histopathological diagnosis of adenomyosis. Tissue sections from the uterine isthmus were stained for nerves with PGP 9.5 using a standard immunohistochemical regimen. In group 1 (n = 25, normal histological report), normal innervation of the uterine isthmus included concentrations of nerves in the subserosal layers and at the endometrial-myometrial interface with sparse, neurovascular bundles distributed throughout the myometrial stroma. In group 2, (n = 23 with adenomyosis), there were no nerves in areas of adenomyosis and absence of nerves at the endometrial-myometrial nerve plexus. Focal proliferation of small-diameter nerve fibres was observed at the margins of adenomyosis in some uteri. Subserosal nerve fibres were still present in those sections that extended to include this region. Adenomyosis is associated with loss of nerve fibres at the endometrial-myometrial interface and absence of nerve fibres in the adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Uterine Neoplasms Uterus Case-Control Studies Endometriosis Female Humans Immunohistochemistry Retrospective Studies Uterine Neoplasms Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (49)

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