Three‐dimensional visualization of uterine nerve fiber distribution using fluorescence micro‐optical sectioning tomography (fMOST): A pilot study

Yongjian Deng, Yirong Zhang, Fei Gao, Yi‐Feng Lin, Pei Li, Yanjuan Qiu, Yongjian Qiu, Lin Yang
In: Journal of Anatomy · 2024 · vol. 246(5) , pp. 812–818 · doi:10.1111/joa.14157 · PMID:39436402 · W4403638621
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Fluorescence micro-optical sectioning tomography (fMOST) revealed a radial dispersion of uterine nerve fibers from myometrium to endometrium, with dense, flower-like terminations in the cervix and sparse, vine-like patterns in the corpus.

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Abstract

STUDY OBJECTIVE: This study aimed to observe and quantitatively analyze the morphology and distribution of uterine nerve fibers using fluorescence micro-optical sectioning tomography (fMOST). The goal was to provide an accurate morphological reference for pathological evaluations of uterine nerves. MEASUREMENTS AND MAIN RESULTS: Using fMOST technique, we observed and analyzed the distribution of nerve fibers within the uterus. Our findings revealed a radial dispersion of nerve fibers radiating from myometrium to endometrium. The cervix uteri region exhibited a high density of nerve fibers, displaying terminations in a flower spray pattern. In contrast, nerve fibers in corpus uteri were comparatively sparse. However, we identified a unique "vine-like" pattern of a single nerve fiber extending from myometrium to endometrial layer in areas with concentrated nerves. CONCLUSIONS: The fMOST technique is able to effectively elucidate the morphology and distribution of uterine nerve fibers. This method enables three-dimensional visualization of nerves in myometrium and offers a novel approach to observe the pathological changes in uterine nerves.

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