The Role of the Myometrium in Adenomyosis

Marwan Habiba, Giuseppe Benagiano
In: Uterine Adenomyosis · 2015 · pp. 81–102 · doi:10.1007/978-3-319-13012-5_5 · W2297969602
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Differences exist between the inner and outer myometrium and in uteri with and without adenomyosis, suggesting the myometrium may play a role in adenomyosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews how the uterine myometrium is involved in adenomyosis, focusing on how modern imaging differentiates the inner versus outer myometrium and how uteri with versus without adenomyosis show demonstrable differences. It discusses the classical view that hyperplastic-hypertrophic myometrium represents a response to endometrial invasion, while also highlighting more recent literature suggesting the myometrium may contribute to adenomyosis pathogenesis through innate predisposition. A key limitation is that the chapter emphasizes ongoing disagreement in adenomyosis definitions and diagnostic criteria, which complicates interpretation across studies. This paper is centrally about endometriosis and/or adenomyosis — it is centrally about adenomyosis, specifically the role of the myometrium (inner vs outer layers) in adenomyosis.

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adenomyosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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