Measured menstrual blood loss in women with menorrhagia associated with pelvic disease or coagulation disorder.
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This study measured menstrual blood loss in women with pelvic disease or coagulation disorders, finding that leiomyomata and platelet dysfunction often caused excessive bleeding, while other conditions showed variable results.
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Abstract
Fifty-five women with a convincing clinical history of menorrhagia associated with recognizable pelvic disease (40 women) or a confirmed coagulation disorder (15 women) were studied through one or more cycles with measurements of menstrual blood loss volume by a modified alkaline hematin method. Women with leiomyomata almost always exhibited large volumes of menstrual bleeding, which was invariably reduced by myomectomy and sometimes helped by mefenamic acid. Women with other pelvic disease such as endometriosis, adenomyosis, and myometrial hyperplasia also often exhibited genuine menorrhagia that responded to mefenamic acid, whereas others were found to have normal blood loss even when the history was convincing. Some women with coagulation disorders due to platelet dysfunction exhibited gross menorrhagia but others had blood loss within normal limits.
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Cited by (34)
- Adenomyosis and Abnormal Uterine Bleeding: Review of the Evidence 2024
- Early-life factors, in-utero exposures and endometriosis risk: a meta-analysis 2020
- Low Birth Weight Is Strongly Associated with the Risk of Deep Infiltrating Endometriosis: Results of a 743 Case-Control Study 2015
- Low Birth Weight Is Strongly Associated with the Risk of Deep Inltrating Endometriosis: Results of a 743 2015
- The Incidence and Clinical Significance of Adenomyosis 2015
- The Role of the Myometrium in Adenomyosis 2015
- Menstrual Problems for the MRCOG and Beyond 2014
- Understanding clinical features of adenomyosis: a case control study. 2012
- Uterine Artery Embolization for Symptomatic Adenomyosis: A New Technical Development of the 1-2-3 Protocol and Predictive Factors of MR Imaging Affecting Outcomes 2011
- Transvaginal ultrasound for diagnosis of adenomyosis: a review 2006
- Long-Term Results of Uterine Artery Embolization for Symptomatic Adenomyosis 2006
- Benefits and Risks of Pharmacological Agents Used for the Treatment of Menorrhagia 2004
- High Frequency of Endometrial Polyps in Endometriosis 2003
- Human uterine vascular structures in normal and diseased states 2003
- Stromal vascularization in the endometrium during adenomyosis 2003
- Myometrial hyperplasia in pediatric, adolescent, and young adult uteri 2003
- The Clinical Relevance of Disturbances of Uterine Vascular Growth, Remodeling, and Repair 2001
- Morphometric evaluation of stromal vascularization in the endometrium in adenomyosis 1998
- Adenomyosis, Leiomyomata, and Pelvic Pain 1998
- Menstrual Changes During the Perimenopause 1997
- Differential diagnosis of abnormal uterine bleeding 1996
- The association of intrauterine filling defects on hysterosalpingogram with endometriosis 1996
- Menorrhagia: a clinical update 1996
- Adenomyosis 1995
- 8 Prostaglandins, prostaglandin inhibitors and their roles in gynaecological disorders 1992
- Treatment of Menorrhagia 1992
- Investigation of menorrhagia 1992
- Management of menorrhagia. 1990
- Menorrhagia 1990
- Adenomyosis: 1989
- 11 Treatment of menorrhagia 1989
- Dysfunctional Uterine Bleeding 1988
- Dysfunctional uterine bleeding. 1988
- Eicosanoids, menstruation and menstrual disorders 1987
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