Obstetrics and gynecology

OBJECTIVE: To characterize gynecology clinical trials over time, compare gynecology subspecialties, and analyze factors associated with early discontinuation, results reporting, and publication. METHODS: We conducted a cross-sectional anal…

OBJECTIVE: To evaluate the safety and efficacy of elagolix 150 mg once-daily monotherapy in patients with heavy menstrual bleeding associated with uterine leiomyomas. METHODS: A phase 4, randomized, double-blind, placebo-controlled, 6-mont…

Endometrium was studies histologically, histochemically, and ultrastructurally in a series of biopsies taken from 3 normal, ovulating patients on Days 1-9 of the cycle. The occurrence of ovulation and the adequacy of progesterone were deter…

Uterine leiomyomas are common hormone-responsive neoplasms that frequently cause heavy menstrual bleeding, anemia, pelvic pressure, pain, and adverse reproductive outcomes. In this overview, the efficacy and safety of oral gonadotropin-rele…

OBJECTIVE: To evaluate the prevalence and characteristics of recreational cannabis use in women with pelvic pain, and to examine the influence of cannabis legalization on these parameters. METHODS: We conducted a retrospective analysis of …

Adenomyosis is a heterogeneous, nonmalignant uterine disorder characterized by ectopic endometrium within the myometrium, leading to abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, and subfertility. Once considered a disease o…

INTRODUCTION: Endometriosis is a leading cause of infertility and pelvic pain, with deep infiltrating disease often distorting pelvic anatomy and compromising reproductive potential. Surgical excision is a critical component of management f…

PURPOSE: To provide evidence-based recommendations for the evaluation and diagnosis of endometriosis. TARGET POPULATION: Reproductive-aged adults and adolescents with symptoms suggestive of endometriosis. METHODS: This guideline was devel…

OBJECTIVE: To evaluate the effect of endometriosis medical therapies on bone mineral density (BMD). DATA SOURCES: Electronic databases were searched from inception to July 2025 for clinical studies reporting the effect of hormonal treatmen…

Endometriosis is a chronic condition in which tissue similar to the lining of the uterus grows in other parts of the body. It affects roughly 1 in 10 women of reproductive age, often causing severe pelvic pain and infertility. Despite how c…

ObjectiveRacial disparities in access to minimally invasive surgery remain poorly understood. The objective of this analysis is to examine whether surgeon volume is a determinant in the relationship between patient race and surgical modalit…

OBJECTIVE: To investigate the association between the duration of levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer risk in Korean women. METHODS: A retrospective cohort study was conducted using the Korean Natio…

Endometriosis is an estrogen-dependent, chronic inflammatory disorder characterized by the presence of endometrium-like tissue outside the uterus, affecting approximately 10% of individuals of reproductive age. It contributes to chronic pel…

For many patients with endometriosis, laparoscopic surgery is the most effective treatment to alleviate severe chronic pelvic pain and improve quality of life. Because endometriosis is common among individuals with infertility, surgery is o…

Chronic pelvic pain (CPP) is a complex and often debilitating condition that affects 15-26% of women worldwide. It is defined as pain perceived to originate from pelvic organs or structures that typically lasts longer than 6 months and is o…

BackgroundImaging plays a critical role in evaluating gynecologic emergencies. However, access to such technology is limited in austere environments such as spaceflight. Portable point-of-care ultrasonography (POCUS) offers rapid diagnostic…

ObjectiveTo compare odds of maternal morbidity by mode of becoming pregnant and type of medically assisted reproduction treatments: fertility-enhancing drugs, intrauterine insemination (IUI), and assisted reproductive technology (ART) with …

OBJECTIVE: To evaluate the effectiveness of various medications for the treatment of endometriosis-related pain through a network meta-analysis. DATA SOURCES: A comprehensive search was conducted in PubMed, Embase, Web of Science, and the …

OBJECTIVE: To systematically review predictors associated with persistent pain after hysterectomy performed for individuals with chronic pelvic pain. DATA SOURCES: PubMed and EMBASE were queried from inception to July 2, 2024, searching fo…

OBJECTIVE: To assess disparities in medical and surgical management of endometriosis and pelvic pain disorders, focusing on Black individuals and individuals from other racial and ethnic groups within an integrated health care delivery syst…

Endometriosis is a chronic inflammatory condition that has been linked to mental health outcomes. We conducted a population-based, retrospective, matched cohort study using administrative health data (2010-2022) from Ontario, Canada, to ass…

OBJECTIVE: To assess the effects of demographic shifts, changes in contemporaneous clinical practices, and technologic innovation on assisted reproductive technology (ART) success rates by conducting an analysis of cumulative live-birth rat…