Eicosanoids, menstruation and menstrual disorders

Ian S. Fraser
In: Eicosanoids and Reproduction · 1987 · pp. 30–62 · doi:10.1007/978-94-009-3215-9_2 · W185194853
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Eicosanoids are synthesized in uterine tissues and play significant roles in normal physiological uterine functions as well as pathological disturbances, particularly menstruation and menstrual disorders.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper reviews evidence that eicosanoids—especially prostaglandins synthesized in the endometrium and acting on uterine tissues—play major roles in normal uterine physiology and in pathological disturbances, with particular emphasis on menstruation and “menstrual disorders.” It synthesizes findings from human and animal studies measuring prostaglandin levels, release from uterine tissues during the menstrual cycle, and receptor/binding profiles, and it discusses how these mediators may relate to processes such as uterine contractility and menstrual blood loss, including in dysmenorrhea and dysfunctional uterine bleeding. A stated limitation of the review format is that it is largely based on accumulating disparate mechanistic and observational studies rather than presenting new controlled data. Relevance to endometriosis: the review is centrally focused on menstruation physiology and menstrual disorders, which are closely related to the endometriosis-associated experience of cyclical pelvic pain and abnormal bleeding, though the provided text does not explicitly discuss endometriosis or adenomyosis.

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last seen: 2026-06-10T17:14:06.276822+00:00
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