Prostaglandin biosynthesis inhibitors and endometriosis

A Kauppila, Antti Kauppila, Kauppila A, Jukka Puolakka, Puolakka J, J Puolakka, Ylikorkala O, Olavi Ylikorkala, O Ylikorkala
Prostaglandins · 1979 · vol. 18(4) , pp. 655–661 · doi:10.1016/0090-6980(79)90033-9 · PMID:531232 · W2046183301
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This paper investigates the role of prostaglandin biosynthesis inhibitors in endometriosis, exploring their mechanisms and potential therapeutic applications.

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Abstract

Prostaglandins (PGs) may be involved in the development of the symptoms of endometriosis. Therefore 18 patients with pelvic endometriosis were treated in placebo controlled double-blind trial with different prostaglandin biosynthesis inhibitors. These drugs were: acetylsalicylic acid (0.5 g x 3) exerting a weak PG-synthetase inhibition, indomethacin (25 mg x 3) inhibiting PG-synthetase, and as a representative of fenamates, tolfenamic acid (200 mg x 3), which both inhibits PG-synthetase and antagonizes PGs at the target level. The therapeutic effect was evaluated using a specific endometriosis score separately during menstruation and in premenstrum. Prostaglandin biosynthesis inhibitors did not alleviate premenstrual complaints better than placebo. During menstruation tolfenamic acid relieved endometriotic symptoms more effectively than placebo while indomethacin and acetylsalicylic acid did not differ from placebo. A drug which inhibit both the synthesis and action of PGs can thus be used in the alleviation of secondary dysmenorrhea due to endometriosis.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Endometriosis Pelvic Neoplasms Prostaglandin Antagonists Aspirin Aspirin Double-Blind Method Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Female Humans Indomethacin Indomethacin ortho-Aminobenzoates ortho-Aminobenzoates Pelvic Neoplasms Pelvic Neoplasms Placebos

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (43)

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License: CC0 · commercial use OK