STUDIES IN THE INVOLVEMENT OF PROSTAGLANDINS IN UTERINE SYMPTOMATOLOGY AND PATHOLOGY

E A Willman, Eve A. Willman, William P. Collins, W P Collins, S G Clayton
British journal of obstetrics and gynaecology · 1976 · vol. 83(5) , pp. 337–341 · doi:10.1111/j.1471-0528.1976.tb00839.x · PMID:1268141 · W2060042161
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Prostaglandin E2 and F2alpha concentrations in endometrial tissue varied significantly across menstrual cycle phases and were elevated in women with uterine fibromyomata, dysmenorrhea, irregular bleeding, endometriosis, and endometrial carcinoma.

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Abstract

The concentrations of prostaglandin E2 and F2alpha were measured by radioimmunoassay in samples of endometrial tissue from 155 women. The results showed that the concentration of prostaglandins E2 (ng/100 mg of wet tissue; mean +/- SD) in tissue from apparently healthy women with regular menstrual cycles was 79-3 +/- 9-9 during the menstrual period. The level in the proliferative and early secretory phases fell to 11-8 +/- 4-0 and 13-3 +/- 8-3 respectively. During the late secretory phase there was a significant increase to 20-1 +/- 10-8. The corresponding values from patients with fibromyomata and without menorrhagia were similar. However, the concentration in tissue from patients with fibromyomata and menorrhagia was significantly higher (63-9 +/- 17-9) during the secretory phase of the uterine cycle. In addition, the amount was significantly higher in the groups with dysmenorrhoea (19-0 +/- 4-5 proliferative; 68-0 +/-18-15 secretory) and irregular uterine bleeding (78-3 +/- 59-0 proliferative; 87-4 +/- 64-9 secretory). The mean concentration was higher in cases of endometriosis, and significantly elevated in endometrial carcinoma. The results for prostaglandin F2alpha showed a similar pattern, but the changes were less marked in patients with irregular dysfunctional bleeding. The findings are discussed.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Endometrium Menstruation Prostaglandins E Prostaglandins F Uterine Diseases Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometrium Female Humans Leiomyoma Leiomyoma Prostaglandins E Prostaglandins F Uterine Diseases Uterine Hemorrhage Uterine Hemorrhage Uterine Neoplasms

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