Abnormal Expression of Prostaglandins E2 and F2αReceptors and Transporters in Patients with Endometriosis

Halima Rakhila, Nathalie Bourcier, Ali Akoum, Marc Pouliot
BioMed research international · 2015 · vol. 2015 , pp. 1–11 · doi:10.1155/2015/808146 · PMID:26240828 · W1606651386
article OA: hybrid CC0 ⤵ 16 in-corpus citations
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This study found increased expression of prostaglandin E2 and F2α receptors and transporters in the ectopic and eutopic endometrium of women with endometriosis.

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Abstract

OBJECTIVE: To investigate the level of expression of prostaglandin receptivity and uptake factors in eutopic and ectopic endometrium of women with endometriosis. DESIGN: Prospective study. SETTING: Human reproduction research laboratory. PATIENTS: Seventy-eight patients with endometriosis and thirty healthy control subjects. INTERVENTION(S): Endometrial and endometriotic tissue samples were obtained during laparoscopic surgery. MAIN OUTCOME MEASURE(S): Real-time polymerase chain reaction assay of mRNA encoding prostaglandin E2 receptors (EP1, EP2, EP3, and EP4), prostaglandin F2α receptor (FP), prostaglandin transporter (PGT), and multidrug resistance-associated protein 4 (MRP4); immunohistochemical localization of expressed proteins. RESULTS: Marked increases in receptors EP3, EP4, and FP and transporters PGT and MRP4 in ectopic endometrial tissue were noted, without noticeable change associated with disease stage. An increase in EP3 expression and decreases in FP and PGT were observed in the eutopic endometrium of endometriosis patients in conjunction with the phases of the menstrual cycle. CONCLUSION(S): This study is the first to demonstrate a possible relationship between endometriosis and enhanced prostaglandin activity. In view of the wide range of prostaglandin functions, increasing cell receptivity and facilitating uptake in endometrial tissue could contribute to the initial steps of overgrowth and have an important role to play in the pathogenesis and symptoms of this disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

ATP-Binding Cassette, Sub-Family C Proteins Endometriosis Endometrium Organic Anion Transporters Receptors, Prostaglandin Receptors, Prostaglandin E Adult ATP-Binding Cassette, Sub-Family C Proteins Biomarkers Biomarkers Endometriosis Endometriosis Endometrium Female Humans Organic Anion Transporters Receptors, Prostaglandin Receptors, Prostaglandin E Reproducibility of Results Sensitivity and Specificity

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (70)

Cited by (16)

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