Augmented Angiogenic Factors Expression via FP Signaling Pathways in Peritoneal Endometriosis

Halima Rakhila, Mahera Al-Akoum, Mahéra Al-Akoum, Charles Doillon, Charles J. Doillon, Nicolas Lacroix-Pépin, Nicolas Lacroix‐Pepin, Mathieu Leboeuf, Mathieu Lebœuf, Madeleine Lemyre, Ali Akoum, Marc Pouliot
The Journal of clinical endocrinology and metabolism · 2016 · vol. 101(12) , pp. 4752–4763 · doi:10.1210/jc.2016-1569 · PMID:27726474 · W2530909928
article OA: bronze CC0 ⤵ 8 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated how the F-prostanoid receptor pathway influences angiogenesis in peritoneal endometriosis by examining the expression of FP, VEGF, and CXCL8.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

CONTEXT: is a potent angiogenic factor in endothelial cells. OBJECTIVE: We sought to determine whether or not the F-prostanoid receptor modulates angiogenesis in ectopic stromal cells. DESIGN: signaling was assessed. SETTING: The study was conducted in an immunology laboratory at the Centre Hospitalier Universitaire (Québec City) medical research center. PATIENTS: Women found to have peritoneal endometriosis during laparoscopy were included in this study. MAIN OUTCOME MEASURE(S): , vascular endothelial cell growth factor, and CXC chemokine ligand 8 mRNA and protein; FP prostanoid receptor expression. RESULTS: can exert its proliferative and angiogenic activities either directly by stimulating endothelial cell proliferation, migration and angiogenesis through F-prostanoid receptor, or indirectly, by stimulating endometriotic stromal cells to produce potent angiogenic factors through either receptor variant. CONCLUSION: in endometriosis-associated angio-inflammatory changes.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inducing Agents Dinoprost Endometriosis Peritoneal Diseases Receptors, Prostaglandin Signal Transduction Adult Angiogenesis Inducing Agents Angiogenesis Inducing Agents Cells, Cultured Dinoprost Dinoprost Endometriosis Female Humans Peritoneal Diseases Receptors, Prostaglandin Stromal Cells Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (71)

Cited by (8)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:49.724109+00:00
License: CC0 · commercial use OK