CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis

Vaiyapuri P. Sumathi, V P Sumathi, W. Glenn McCluggage, W G McCluggage
Journal of clinical pathology · 2002 · vol. 55(5) , pp. 391–392 · doi:10.1136/jcp.55.5.391 · PMID:11986349 · W2143473688
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that CD10 immunoreactivity is maintained in ectopic endometrial stroma and can help confirm endometriosis diagnoses when morphology is unclear.

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Abstract

AIMS: Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis. METHODS/RESULTS: Twenty five cases of endometriosis were stained with a commercially available antibody against CD10. Endometrial stromal cells were positive in 22 of 25 cases. There was little or no staining of other tissues. CONCLUSIONS: CD10 immunoreactivity is largely maintained in endometrial stromal cells located outside the uterus. Immunohistochemical staining with CD10 may be of value in confirming a diagnosis of endometriosis when there is morphological doubt.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Female Urogenital Diseases Intestinal Diseases Neprilysin Peritoneal Diseases Biomarkers Biomarkers Cicatrix Cicatrix Endometriosis Female Female Urogenital Diseases Humans Immunohistochemistry Immunohistochemistry Intestinal Diseases Neprilysin Peritoneal Diseases Stromal Cells Stromal Cells

Citation neighborhood

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References (7)

Cited by (50)

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