Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas

Michael A Mederos, Nicole Villafañe, Sadhna Dhingra, Carlos Farinas, Carlos A. Farinas, Amy L. McElhany, Amy McElhany, William E Fisher, George Van Buren Ii, George Van Buren
World journal of gastroenterology · 2017 · vol. 23(6) , pp. 1113 · doi:10.3748/wjg.v23.i6.1113 · PMID:28246486 · W2586903056
article OA: hybrid CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report details a pancreatic endometrial cyst that mimicked a mucinous cystic neoplasm due to overlapping imaging and laboratory findings.

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Abstract

Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16 cm × 12 cm × 4 cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. Here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas.

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Condition tags

mesh:D004715

MeSH descriptors

Endometriosis Neoplasms, Cystic, Mucinous, and Serous Pancreatic Cyst Pancreatic Neoplasms Pancreatitis Abdominal Pain Abdominal Pain Adult Amylases Amylases Carcinoembryonic Antigen Carcinoembryonic Antigen Diagnosis, Differential Diarrhea Diarrhea Endometriosis Endosonography Fatigue Fatigue Female

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