Pancreatic endometriosis

In: Bulletin of the Academy of Sciences of Moldova. Medical Sciences · 2024 · vol. 79(2) , pp. 256–260 · doi:10.52692/1857-0011.2024.2-79.49 · W4410457798
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This systematic literature review identified and analyzed 20 cases of pancreatic endometriosis reported between 1984 and 2024.

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This paper reports a systematic literature review of pancreatic endometriosis, identifying 20 published cases from 1984–2024 using a PRISMA-guided search of PubMed and Google Scholar. Across reported cases, pancreatic involvement by endometriosis is characterized as very rare and often described in forms such as pancreatic endometrial cysts/endometriomas that can resemble other pancreatic lesions. The authors’ main limitation is that the underlying evidence consists of case reports and case series rather than prospective studies, limiting the ability to draw generalizable conclusions about incidence, presentation, or outcomes. This paper is centrally about endometriosis — specifically pancreatic endometriosis via a systematic review of rare reported cases.

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Abstract

Endometriosis is a pathological condition characterized by the presence of endometrial glands and stroma in ectopic sites, although pancreatic involvement has been described very rarely. A systematic literature review was performed, according to the PRISMA statement from PubMed and Google Scholar with the identification of 20 cases reported in the period 1984-2024.
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Pancreatic endometriosis DOI: https://doi.org/10.52692/1857-0011.2024.2-79.49Keywords: pancreas, endometriosis, pancreatic endometriosisAbstract Endometriosis is a pathological condition characterized by the presence of endometrial glands and stroma in ectopic sites, although pancreatic involvement has been described very rarely. A systematic literature review was performed, according to the PRISMA statement from PubMed and Google Scholar with the identification of 20 cases reported in the period 1984-2024. References Gkegkes ID, Fotiou A, Mavroeidis VK, Gerogiannis IN, Iavazzo C. Pancreatic endometriosis: a systematic review. Ann Gastroenterol. 2023;36(1):61-67. Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-7. Andres MP, Arcoverde FVL, Souza CCC, Fernandes LFC, Abrão MS, Kho RM. Extrapelvic endometriosis: A systematic review. J Minim Invasive Gynecol. 2020;27(2):373-389. Hirata T, Koga K, Osuga Y. Extra-pelvic endometriosis: A review. Reprod Med Biol. 2020;19(4):323-333. Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Goulielmos GN, Kalogiannidis I.Abdominal and perineal scar endometriosis: retrospective study on 40 cases. Eur J Obstet Gynecol Reprod Biol. 2020;252:225-227. Nisolle M, Pasleau F, Foidart JM. L’endométriose extragénitale [Extragenital endometriosis]. J Gynecol Obstet Biol Reprod (Paris). 2007;36(2):173-8. Marchevsky AM, Zimmerman MJ, Aufses AH Jr, Weiss H. Endometrial cyst of the pancreas. Gastroenterology. 1984;86(6):1589-91. Goswami AK, Sharma SK, Tandon SP, Malik N, Mathur RP, Malik AK, Bapna BC. Pancreatic endometriosis presenting as a hypovascular renal mass. J Urol. 1986;135(1):112-3. Verbeke C, Härle M, Sturm J. Cystic endometriosis of the upper abdominal organs. Report on three cases and review of the literature. Pathol Res Pract. 1996;192(3):300-4; discussion 305. Sumiyoshi Y, Yamashita Y, Maekawa T, Sakai T, Shirakusa T. A case of hemorrhagic cyst of the pancreas resembling the cystic endometriosis. Int Surg. 2000;85(1):67-70. Lee DS, Baek JT, Ahn BM, Lee EH, Han SW, Chung IS, Sun HS, Park DH. A case of pancreatic endometrial cyst. Korean J Intern Med. 2002;17(4):266-9. Tunuguntla A, Van Buren N, Mathews MR, Ehrenfried JA. Endometriosis of the pancreas presenting as a cystic pancreatic neoplasm with possible metastasis. South Med J. 2004;97(10):1020-1. Loja Oropeza D, Alvizuri Escobedo J, Vilca Vasquez M, Altamirano Bautista J. Endometriosis pancreática [Endometriosis of the pancreas]. Rev Gastroenterol Peru. 2009;29(1):55-60. Oishi M, Hashida H, Yuba Y, Takabayashi A. Pancreatic endometrial cyst: report of a case. Surg Today. 2011;41(7):1011-5. Monrad-Hansen PW, Buanes T, Young VS, Langebrekke A, Qvigstad E. Endometriosis of the pancreas. J Minim Invasive Gynecol. 2012;19(4):521-3. Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H. 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Pancreatic endometrioma presenting with spontaneous hemorrhagic rupture. Pancreas. 2020;49(3):e23-e24. Huang B, Mooser A, Carpenter D, Montenegro G, Luu C. A Rare Case of Pancreatic Endometriosis masquerading as pancreatic mucinous neoplasm. Case Rep Surg. 2021;2021:5570290. Ludwig C, Kopacz A, Warren ML, Onkendi E. Symptomatic pancreatic body endometrial cyst requiring en bloc distal pancreatectomy. BMJ Case Rep. 2021;14(9):e244911. AlNuaimi D, Akmal Y, AlDuaij A, Sherif A, Abdulghaffar S, Cem Balci N. Pancreatic endometrioma : a rare differential diagnosis for a pseudocyst. BJR Case Rep. 2023;9(1):20220141. Naseer A, Davis BM, Serji SA. Endometriosis beyond the pelvis: a case of pancreatic involvement. Cureus. 2024;16(9):e70530. Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H. Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol. 2002;83(1-5):149-55. Veeraswamy A, Lewis M, Mann A, Kotikela S, Hajhosseini B, Nezhat C. Extragenital endometriosis. Clin Obstet Gynecol. 2010;53(2):449-66. Chamié LP, Ribeiro DMFR, Tiferes DA, Macedo Neto AC, Serafini PC. Atypical sites of deeply infiltrative endometriosis: clinical characteristics and imaging findings. Radiographics. 2018;38(1):309-328. Artifon EL, Franzini TA, Kumar A, Matsura PF, Furuya CK Jr, Ishioka S, Sakai P. EUS-guided FNA facilitates the diagnosis of retroperitoneal endometriosis. Gastrointest Endosc. 2007;66(3):620-2. Song L, Xing A, Li Q, Wang G. High-grade serous carcinoma resulting from rectal endometriosis and complicated with ovarian cancer. Front Oncol. 2019;9:1252. Downloads Published License Copyright (c) 2025 Bulletin of the Academy of Sciences of Moldova. Medical Sciences This work is licensed under a Creative Commons Attribution 4.0 International License.

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