Endometriosis‐related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions

W. Glenn McCluggage
Histopathology · 2019 · vol. 76(1) , pp. 76–92 · doi:10.1111/his.13970 · PMID:31846535 · W2996466614
review OA: closed CC0 ⤵ 52 in-corpus citations
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This review discusses uncommon benign, premalignant, and malignant lesions associated with endometriosis, focusing on diagnostic challenges and rare neoplastic transformations.

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Abstract

Endometriosis is an extremely common condition and, in most cases, establishing a histological diagnosis is straightforward, although a variety of benign alterations may result in problems with interpretation. In this review, I discuss selected uncommon variants of endometriosis or benign alterations that may result in diagnostic problems. The topics covered include the contentious issue of so-called atypical endometriosis, stromal endometriosis, polypoid endometriosis, and the association of endometriosis with florid mesothelial hyperplasia. The propensity of endometriosis to undergo neoplastic transformation (especially to endometrioid and clear cell carcinoma) is well known. Selected issues relating to the various neoplasms that can arise in endometriosis are discussed, with a particular concentration on unusual variants of endometrioid carcinoma that result in a disproportionately high number of issues in referral practice. The propensity of ovarian endometrioid carcinomas to show an unexpected ('aberrant') immunophenotype with positive staining with 'intestinal' markers and negative staining with Mullerian markers is also discussed. Uncommon tumour types that may arise in endometriosis, namely seromucinous neoplasms, mesonephric-like carcinomas, and somatically derived yolk sac tumours, are also covered.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Endometrium Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Endometrium Female Humans Hyperplasia Hyperplasia Precancerous Conditions Precancerous Conditions

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (80)

Cited by (50)

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License: CC0 · commercial use OK