Ovarian Mesonephric-Like Adenocarcinoma Arising from an Endometriotic Cyst with an Identical KRAS Mutation in Both Components: A Case Report
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This case report describes an ovarian mesonephric-like adenocarcinoma arising from an endometriotic cyst that shared an identical KRAS mutation in both components.
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Abstract
Mesonephric-like adenocarcinoma (MLA) is a rare tumor that occurs in the uterine corpus and ovary. It shares the morphological and immunohistochemical features of cervical mesonephric adenocarcinoma. Recent reports have suggested that a majority of ovarian MLAs are associated with endometriosis. Herein, we report the novel tumor of a 54-year-old Japanese woman with a history of bilateral ovarian endometriotic cysts who presented with abdominal distension. Pelvic magnetic resonance imaging revealed a 14-cm left ovarian cystic tumor with an intra-cystic solid mass. Histological examination revealed proliferation of columnar or cuboidal tumor cells forming round tubules, irregular tubular glands, fused glands, papillary structures, and solid nests.Additionally, associated endometriosis was observed in the cyst wall. The tumor cells were diffusely positive for GATA-binding protein 3 (GATA3) and negative for estrogen receptor. The tumor cells also showed wild-type p53, with retained expression of AT-rich interactive domain-containing protein 1A (ARID1) and phosphatase and tensin homolog (PTEN). Molecular analysis revealed an identical KRAS p.G12V mutation in the tumor and the endometriotic cyst. The present tumor elucidates the pathogenesis and molecular mechanisms of ovarian MLA and demonstrates that ovarian MLA is an endometriosis-associated neoplasm. Further investigation into the pathogenesis and molecular mechanisms of ovarian MLA may assist in identifying potential therapeutic targets for this rare condition.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (4)
- Cancer-Associated Mutations in Endometriosis without Cancer 2017
- Endometriosis‐related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions 2019
- Two Cases of Mesonephric-like Carcinoma Arising From Endometriosis: Case Report and Review of the Literature 2022
- Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases 2023
References (14)
- Cancer-Associated Mutations in Endometriosis without Cancer via openalex
- Endometriosis‐related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions via openalex
- Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases via openalex
- Two Cases of Mesonephric-like Carcinoma Arising From Endometriosis: Case Report and Review of the Literature via openalex
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Source provenance
- europepmc
- last seen: 2026-06-15T06:13:43.845377+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-06-15T06:10:42.520816+00:00
- unpaywall
- last seen: 2026-06-13T06:42:57.164913+00:00
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