Ovarian Mesonephric-Like Adenocarcinoma Arising from an Endometriotic Cyst with an Identical KRAS Mutation in Both Components: A Case Report

Eto C, Chika Eto, Tsubasa Hiraki, Takuya Kawata, Kawata T, Nobutaka Takahashi, Takahashi N, Hirashima Y, Yasuyuki Hirashima
International journal of surgical pathology · 2025 · vol. 33(8) , pp. 1778–1783 · doi:10.1177/10668969251333437 · PMID:40232302 · W4409480721
case-report OA: closed CC0
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This case report describes an ovarian mesonephric-like adenocarcinoma arising from an endometriotic cyst that shared an identical KRAS mutation in both components.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-17 · read from full text ⓘ

This case report describes a rare instance of ovarian mesonephric-like adenocarcinoma developing from an endometriotic cyst, confirmed by the presence of an identical KRAS mutation in both the benign and malignant tissue components. The authors utilized molecular genetic analysis to establish the clonal relationship between the precursor lesion and the resulting carcinoma, highlighting a potential molecular pathway for malignant transformation. This finding provides direct pathological evidence linking endometriosis to the development of specific ovarian malignancies through shared genetic alterations. This paper is centrally about endometriosis — specifically its role as a precursor lesion for ovarian cancer via the formation of endometriotic cysts.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Mesonephric-like adenocarcinoma (MLA) is a rare tumor that occurs in the uterine corpus and ovary. It shares the morphological and immunohistochemical features of cervical mesonephric adenocarcinoma. Recent reports have suggested that a majority of ovarian MLAs are associated with endometriosis. Herein, we report the novel tumor of a 54-year-old Japanese woman with a history of bilateral ovarian endometriotic cysts who presented with abdominal distension. Pelvic magnetic resonance imaging revealed a 14-cm left ovarian cystic tumor with an intra-cystic solid mass. Histological examination revealed proliferation of columnar or cuboidal tumor cells forming round tubules, irregular tubular glands, fused glands, papillary structures, and solid nests.Additionally, associated endometriosis was observed in the cyst wall. The tumor cells were diffusely positive for GATA-binding protein 3 (GATA3) and negative for estrogen receptor. The tumor cells also showed wild-type p53, with retained expression of AT-rich interactive domain-containing protein 1A (ARID1) and phosphatase and tensin homolog (PTEN). Molecular analysis revealed an identical KRAS p.G12V mutation in the tumor and the endometriotic cyst. The present tumor elucidates the pathogenesis and molecular mechanisms of ovarian MLA and demonstrates that ovarian MLA is an endometriosis-associated neoplasm. Further investigation into the pathogenesis and molecular mechanisms of ovarian MLA may assist in identifying potential therapeutic targets for this rare condition.
Full text 1,629 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

Get full access to this article View all access and purchase options for this article. Data availability statement

References

Cite Cite Cite Download to reference manager If you have citation software installed, you can download citation data to the citation manager of your choice Information, rights and permissions Information Published In https://www.webofscience.com/api/gateway/wos/peer-review/10.1177/10668969251333437

Keywords

Data availability statement Article versions Authors Metrics and citations Metrics Journals metrics This article was published in International Journal of Surgical Pathology. View All Journal MetricsPublication usage* Total views and downloads: 126 *Publication usage tracking started in December 2016 Publications citing this one Receive email alerts when this publication is cited Web of Science: 1 view articles Opens in new tab Crossref: 1 - Clinicopathology of adenocarcinoma originating from the anal gland with immunohistochemical expressions of GATA3 and TTF-1: a case report and literature review Figures and tables Figures & Media Tables View Options Access options If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below: loading institutional access options Alternatively, view purchase options below: Purchase 24 hour online access to view and download content. Access journal content via a DeepDyve subscription or find out more about this option.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

References (14)

Source provenance

europepmc
last seen: 2026-09-21T06:08:07.822426+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-09-21T06:05:10.549393+00:00
unpaywall
last seen: 2026-09-21T07:16:15.697306+00:00
License: CC0 · commercial use OK