Endometriosis: Three-year histopathological perspective from the largest hospital in Africa

Mashele T, Thembi Mashele, Yavini Reddy, Y. Raghavendra Reddy, Reddy Y, Sugeshnee Pather, Pather S
Annals of diagnostic pathology · 2020 · vol. 45 , pp. 151458 · doi:10.1016/j.anndiagpath.2019.151458 · PMID:31951968 · W2998917328
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This paper presents a three-year histopathological analysis of endometriosis cases from the largest hospital in Africa, detailing observed patterns and characteristics.

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Abstract

BackgroundEndometriosis refers to the presence of ectopic endometrial tissue outside the uterus, that may result in infertility or recurrent implantation failure.AimsWe aimed to document the number of histopathologically confirmed cases of endometriosis at the largest hospital in Africa during a three-year timeframe. Age, topographic site, pathological components, CD10 immunohistochemistry, metaplasia and associated neoplasms were documented.MethodA retrospective, descriptive cross-sectional review of confirmed cases of endometriosis was conducted.ResultsThirty-four (n = 34) patients were confirmed to have endometriosis within 43 topographic sites. More than one topographic site of involvement was documented in 5 patients. The age range was 24 to 58 years [median age 36.4 ± 8.03; mean 34.5 ± 8.03 yrs]. The most frequent diagnostic combination was the triad of endometrial glands, stroma and chronic haemorrhage as confirmed in 53% of the cases. The most frequent topographic site of involvement was the ovary (27.9%) followed by the fallopian tubes (16.7%), umbilical region (13.9%), and abdominal wall (11.6%). Endometriotic cyst was reported in 10 cases (29.4%) and the ovary was the most common site in which endometriotic cysts occurred (p < .01). Endometrioma was only confirmed at the abdominal wall of one patient. CD10 immunochemistry was requested in 5 cases and confirmed the presence of endometrial stroma in all cases tested. Ciliated metaplasia was common (62%). Endometriosis was documented incidentally in context of two cases of neoplasia (pre-invasive and invasive).ConclusionEndometriosis is diagnosed predominantly, but not exclusively, in women of child-bearing age. Ovarian involvement has a propensity to develop endometriotic cysts. CD10 immunohistochemistry has diagnostic value when endometrial stroma is limited or inconspicuous.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunohistochemistry Neprilysin Adult Africa Africa Cross-Sectional Studies Cysts Cysts Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Fallopian Tubes Fallopian Tubes Female Hemorrhage Hemorrhage

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