Endometriosis: Three-year histopathological perspective from the largest hospital in Africa

Mashele T, Thembi Mashele, Yavini Reddy, Y. Raghavendra Reddy, Reddy Y, Sugeshnee Pather, Pather S
Annals of diagnostic pathology · 2020 · vol. 45 , pp. 151458 · doi:10.1016/j.anndiagpath.2019.151458 · PMID:31951968 · W2998917328
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This paper presents a three-year histopathological analysis of endometriosis cases from the largest hospital in Africa, detailing observed patterns and characteristics.

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Abstract

BACKGROUND: Endometriosis refers to the presence of ectopic endometrial tissue outside the uterus, that may result in infertility or recurrent implantation failure. AIMS: We aimed to document the number of histopathologically confirmed cases of endometriosis at the largest hospital in Africa during a three-year timeframe. Age, topographic site, pathological components, CD10 immunohistochemistry, metaplasia and associated neoplasms were documented. METHOD: A retrospective, descriptive cross-sectional review of confirmed cases of endometriosis was conducted. RESULTS: Thirty-four (n = 34) patients were confirmed to have endometriosis within 43 topographic sites. More than one topographic site of involvement was documented in 5 patients. The age range was 24 to 58 years [median age 36.4 ± 8.03; mean 34.5 ± 8.03 yrs]. The most frequent diagnostic combination was the triad of endometrial glands, stroma and chronic haemorrhage as confirmed in 53% of the cases. The most frequent topographic site of involvement was the ovary (27.9%) followed by the fallopian tubes (16.7%), umbilical region (13.9%), and abdominal wall (11.6%). Endometriotic cyst was reported in 10 cases (29.4%) and the ovary was the most common site in which endometriotic cysts occurred (p < .01). Endometrioma was only confirmed at the abdominal wall of one patient. CD10 immunochemistry was requested in 5 cases and confirmed the presence of endometrial stroma in all cases tested. Ciliated metaplasia was common (62%). Endometriosis was documented incidentally in context of two cases of neoplasia (pre-invasive and invasive). CONCLUSION: Endometriosis is diagnosed predominantly, but not exclusively, in women of child-bearing age. Ovarian involvement has a propensity to develop endometriotic cysts. CD10 immunohistochemistry has diagnostic value when endometrial stroma is limited or inconspicuous.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunohistochemistry Neprilysin Adult Adult Africa Africa Africa Cross-Sectional Studies Cross-Sectional Studies Cysts Cysts Cysts Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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