Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis

SiHyun Cho, Young Sik Choi, Choi YS, Jeon YE, Young Eun Jeon, Kyung Jin Im, Im KJ, Young Mi Choi, Choi YM, Young Choi, Su Youn Yim, Yim SY, HyeYeon Kim, Kim H, Seok Kyo Seo, Byung Seok Lee
Microvascular research · 2012 · vol. 83(2) , pp. 237–242 · doi:10.1016/j.mvr.2011.12.004 · PMID:22230112 · W2067158566
article OA: green CC0 ⤵ 28 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the expression levels of vascular endothelial growth factor (VEGF) and its soluble receptor-1 (sFlt-1) in endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometrium Peritoneum Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Adult Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Endometrium Female Humans Middle Aged Peritoneum Republic of Korea RNA, Messenger RNA, Messenger Up-Regulation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (28)

Source provenance

europepmc
last seen: 2026-07-28T06:14:09.330459+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:23.388809+00:00
License: CC0 · commercial use OK