Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis

SiHyun Cho, Young Sik Choi, Choi YS, Jeon YE, Young Eun Jeon, Kyung Jin Im, Im KJ, Young Mi Choi, Choi YM, Young Choi, Su Youn Yim, Yim SY, HyeYeon Kim, Kim H, Seok Kyo Seo, Byung Seok Lee
Microvascular research · 2012 · vol. 83(2) , pp. 237–242 · doi:10.1016/j.mvr.2011.12.004 · PMID:22230112 · W2067158566
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This study investigated the expression levels of vascular endothelial growth factor (VEGF) and its soluble receptor-1 (sFlt-1) in endometriosis.

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Abstract

The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometrium Peritoneum Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Adult Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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