Vascular endothelial growth factor and its soluble receptor in ovarian pathology

Paolo Giovanni Artini, P. G. Artini, F Cristello, Cristello F, Francesca Cristello, M Monti, Monti M, Massimiliano Monti, Cela V, V. Cela, Vito Cela, Cesare Battaglia, Battaglia C, C Battaglia, G D'Ambrogio, D'Ambrogio G, G D’Ambrogio, Genazzani AR, A. R. Genazzani, Ar Genazzani
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2005 · vol. 21(1) , pp. 50–56 · doi:10.1080/09513590500099560 · PMID:16048802 · W2091981539
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This study measured VEGF and s-VEGFR-1 levels and their activity index in ovarian cyst fluid, finding higher VEGF in endometriosis and cancer and suggesting the activity index better reflects VEGF's role in these pathologies.

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Abstract

OBJECTIVE: The soluble form of the vascular endothelial growth factor (VEGF) receptor, s-VEGFR-1, may negatively regulate the action of VEGF. Our purpose was to better understand the regulation of angiogenetic processes in ovarian cysts. METHODS: Seventy-three women, 36 with serous cystoadenoma, 30 with ovarian endometriosis and seven with cystoadenocarcinoma, were enrolled. We calculated both VEGF and s-VEGFR-1 levels in cystic fluid and a VEGF activity index by means of the ratio VEGF/s-VEGFR-1. Student's t test was used for the statistical analysis. RESULTS: We found higher VEGF concentration in both endometriotic and malignant lesions than in serous cystoadenoma (p=0.03 and 0.001, respectively). Also s-VEGFR-1 concentration was higher in endometrioma than in serous cysts (p=0.005); however, there was no statistically significant difference between cystoadenoma and the malignant lesions (p=0.15). VEGF activity index in cystoadenoma, endometriotic and malignant lesions was 0.61, 0.27 and 0.50, respectively. CONCLUSIONS: VEGF certainly has an important role in both ovarian endometriosis and for cancer progression; however, the activity index may be better to investigate the real role of VEGF in the pathology we have considered.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Ovarian Diseases Ovarian Neoplasms Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Cystadenocarcinoma Cystadenocarcinoma Cystadenoma, Serous Cystadenoma, Serous Cyst Fluid Cyst Fluid Endometriosis Endometriosis Female Humans Ovarian Diseases Ovarian Neoplasms Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1

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