Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis

Vladimir Bourlev, Bourlev V, Natalia Iljasova, Iljasova N, Leyla Adamyan, Adamyan L, Larsson A, Anders Larsson, Matts Olovsson, Olovsson M
Fertility and sterility · 2010 · doi:10.1016/j.fertnstert.2009.02.019 · PMID:19324337
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Women with endometriosis showed elevated pro-angiogenic factors that partially normalized in serum after surgical lesion removal.

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Abstract

OBJECTIVE: To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers. DESIGN: Patients with endometriosis before and after surgery were compared with control patients. SETTING: University Hospital. PATIENT(S): Twenty-one healthy controls and 32 women with advanced endometriosis. INTERVENTION(S): In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy. MAIN OUTCOME MEASURE(S): Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery. RESULT(S): Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF. CONCLUSION(S): Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Neovascularization, Pathologic Neovascularization, Pathologic Angiopoietin-2 Angiopoietin-2 Angiopoietin-2 Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers Biomarkers Down-Regulation Down-Regulation Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium

Funding

funders
[{'doi': '10.13039/100009656', 'name': 'Russian Academy of Medical Sciences', 'awards': []}, {'doi': '10.13039/501100004359', 'name': 'Vetenskapsrådet', 'awards': ['8683']}, {'doi': '10.13039/501100007687', 'name': 'Svenska Läkaresällskapet', 'awards': []}]

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (47)

Source provenance

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