Expression of heparanase and angiopoietin-2 in patients with endometriosis

Jingting C, Jingting Cai, Cai Jingting, Zhang Yang-de, Zhang Yangde, Yangde Z, Yi Z, Zhang Yi, Yi Zhang, Mengxiong L, Li Mengxiong, Mengxiong Li, Yu Rong, Rong Y, Rong Yu, Zhang Yu, Yu Z, Guoqing P, Peng Guoqing, Peng Guo-qing, Peng Li-xiu, Lixiu P, Peng Lixiu
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 136(2) , pp. 199–209 · doi:10.1016/j.ejogrb.2006.09.018 · PMID:17141400 · W2078056956
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This study investigated the expression of heparanase and angiopoietin-2 in endometriosis patients.

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Abstract

ObjectiveThe objective was to investigate the expression of heparanase (Hpa) and angiopoietin-2 (Ang-2) in endometriosis.Study designIn ectopic and eutopic endometrium of patients undergoing laparoscopy for endometriosis (n=86) and in normal endometrium of patients undergoing laparoscopic tubal ligation or hysteroscopic resection because of uterus septus (n=30), we determined Hpa and Ang-2 gene expression by RT-PCR. To support the mRNA data, the expression of Hpa and Ang-2 protein was measured by Western blot analysis. Finally, Hpa and Ang-2 in these tissues was localized by immunohistochemical staining.Result(s)The positive rate of Hpa and Ang-2 mRNA in ectopic and eutopic endometrium in the study group was significantly higher than that in normal endometrium in the control group. In the study group, ectopic and eutopic endometrium expressed a higher positive rate of Hpa and Ang-2 protein, whereas in the control group, normal endometrium expressed a lower positive rate of Hpa and Ang-2 protein. In eutopic and ectopic endometrium, there was balanced expression between Hpa and Ang-2. Both Hpa and Ang-2 showed a balanced expression between eutopic and ectopic endometrium. In ectopic endometrium, strong staining for Hpa and Ang-2 was observed both in epithelial cells and in stromal cells, but in eutopic endometrium, Hpa and Ang-2 were mainly expressed in epithelial cells.ConclusionThe higher expression of Hpa and Ang-2 in ectopic and eutopic endometrium may play an important role in the pathogenesis and development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Angiopoietin-2 Endometriosis Endometrium Glucuronidase Adult Angiopoietin-2 Blotting, Western Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Glucuronidase Heparanase Humans Menstrual Cycle

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