Mesenchymal Stem Cells: A Promising Tool for Targeted Gene Therapy of Endometriosis

Aghila Rani Koippallil Gopalakrishnan, Uday Kishore, Taruna Madan
Regenerative medicine · 2016 · vol. 12(1) , pp. 69–76 · doi:10.2217/rme-2016-0084 · PMID:27900877 · W2559329221
review OA: green CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Endometrial mesenchymal stem cells show promise as a targeted gene therapy approach for endometriosis due to their specificity to the endometrium and flexibility for gene transduction.

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Abstract

Endometriosis is a leading, benign gynecological disorder around the world. Last few years have witnessed tremendous growth in the field of endometriosis and endometrial stem-cell research. Despite advancements in the biology and pathology of endometriosis, disease recurrence is still an enigma. Gene therapy holds promise in treating many pathologic conditions including endometriosis. Mesenchymal stem cells (MSCs) serve as ideal candidates for regenerative medicine and cell-based therapies. Owing to their specificity to the endometrium, residing endometrial MSC populations could be utilized as ideal candidates for targeting endometrial disorders. Recently, we demonstrated their flexibility for gene transduction using adenoviral vectors. The review highlights the potential of endometrial MSCs in devising targeted gene therapies for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Genetic Therapy Mesenchymal Stem Cells Regenerative Medicine Endometriosis Female Humans Mesenchymal Stem Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

Cited by (6)

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