Therapeutic restoration of female reproductive and endocrine dysfunction using stem cells

Xiaobo Liu, Jiajia Li, Wenjun Wang, Xue Ren, Ji-Fan Hu, Ji‐Fan Hu
Life sciences · 2023 · vol. 322 , pp. 121658 · doi:10.1016/j.lfs.2023.121658 · PMID:37023951 · W4362597305
review OA: hybrid CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review details recent advancements and mechanisms of stem cell therapy for treating various female reproductive disorders, including premature ovarian insufficiency and endometriosis, offering new therapeutic avenues.

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Abstract

Millions of women worldwide suffer from infertility associated with gynecologic disorders such as premature ovarian insufficiency, polycystic ovary syndrome, Asherman syndrome, endometriosis, preeclampsia, and fallopian tube obstruction. These disorders can lead to infertility and thereby affect the quality of life of the infertile couple because of their psychological impact and significant costs. In recent years, stem cell therapy has emerged as a therapeutic approach to repair or replace damaged tissues or organs. This review describes the recent development as well as the underlying mechanisms of stem cell therapy for a variety of female reproductive diseases, offering us new therapeutic options for the treatment of female reproductive and endocrine dysfunction.

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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility Infertility, Female Infertility, Female

Citation neighborhood

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References (100)

Cited by (5)

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-06-02T00:34:10.781252+00:00
License: CC0 · commercial use OK