Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Sahar Esfandyari, Rishi Man Chugh, Hang-Soo Park, Elie Hobeika, Mara Ulin, Ayman Al-Hendy, Ayman Al‐Hendy
Cells · 2020 · vol. 9(10) , pp. 2253 · doi:10.3390/cells9102253 · PMID:33050021 · W3085783016
review OA: gold CC0 ⤵ 12 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses recent studies on mesenchymal stem cells' therapeutic use in various female reproductive disorders causing infertility, including their role in microRNA regulation.

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Abstract

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.

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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility, Female Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Exosome Multienzyme Ribonuclease Complex Exosome Multienzyme Ribonuclease Complex Female Humans Infertility, Female Infertility, Female Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cell Transplantation MicroRNAs MicroRNAs Ovarian Follicle Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency

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Cited by (12)

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