Mesenchymal Stem Cell-based Therapy and Female Infertility: Limitations and Advances

Ghajari G, Ghazal Ghajari, Arefe heydari, Heydari A, Ghorbani M, Masoud Ghorbani
Current stem cell research & therapy · 2022 · vol. 18(3) , pp. 322–338 · doi:10.2174/1574888x17666220511142930 · PMID:35546752 · W4280509225
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This review examines female reproductive disorders and current treatments, then evaluates recent advances in using mesenchymal stem cells for infertility and improving women's reproductive health.

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The paper reviews female reproductive disorders that can cause infertility, including premature ovarian failure, polycystic ovary syndrome, endometriosis, and Asherman syndrome, and then evaluates advances in mesenchymal stem cell (MSC)-based therapy for improving reproductive health. It describes MSCs as multipotent cells with high proliferation and multidirectional differentiation potential, highlighting mechanisms such as cell homing, secretion of active factors, and immune regulation. The authors’ key emphasis is that MSCs have fewer ethical restrictions than embryonic stem cells and are therefore receiving attention as a cell-based gynecological treatment, while also framing the work as a synthesis of existing studies rather than presenting new experimental data or specific clinical outcomes. This paper is centrally about endometriosis in the context of female infertility causes, where it is listed among the disorders targeted by MSC-related infertility treatment advances.

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Abstract

Infertility in women can be caused by various female reproductive diseases such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis and Asherman syndrome that affect couples' quality of life and lead to mental, emotional, and physical problems. In recent years, clinical researchers have sought infertility treatments using new methods that are more effective and noninvasive than the old methods. Today, stem cell-based therapy has been introduced as a promising method and an alternative to the old strategy of infertility treatment. Understanding the main features and functional perspective of mesenchymal stem cells (MSCs) in the future of infertility by physicians is crucial. Mesenchymal stem cells (MSCs) are multipotent stem cells with a high proliferation range, abundant source and multidirectional differentiation potential. They have a high potential for the treatment of injured tissues in regenerative medicine through cell homing, secretion of active factors, and participation in immune regulation. At present, due to fewer ethical restrictions on the use of mesenchymal stem cells compared to embryonic stem cells, more attention has been paid to these cells as a new treatment for gynecological disorders. In this paper, we first review the various type of female reproductive disorders along with their common treatment methods, then we evaluate the recent advances in the application of MSCs in the diseases related to infertility and improve the reproductive health of women worldwide.
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Abstract

Infertility in women can be caused by various female reproductive diseases such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis and Asherman syndrome that affect couples' quality of life and lead to mental, emotional, and physical problems. In recent years, clinical researchers have sought infertility treatments using new methods that are more effective and noninvasive than the old methods. Today, stem cell-based therapy has been introduced as a promising method and an alternative to the old strategy of infertility treatment. Understanding the main features and functional perspective of mesenchymal stem cells (MSCs) in the future of infertility by physicians is crucial. Mesenchymal stem cells (MSCs) are multipotent stem cells with a high proliferation range, abundant source and multidirectional differentiation potential. They have a high potential for the treatment of injured tissues in regenerative medicine through cell homing, secretion of active factors, and participation in immune regulation. At present, due to fewer ethical restrictions on the use of mesenchymal stem cells compared to embryonic stem cells, more attention has been paid to these cells as a new treatment for gynecological disorders. In this paper, we first review the various type of female reproductive disorders along with their common treatment methods, then we evaluate the recent advances in the application of MSCs in the diseases related to infertility and improve the reproductive health of women worldwide.

Keywords

Pluripotent stem cell, female reproduction, assisted reproductive technologies, biotechnologies of reproduction, cell-based therapy, mesenchymal stem cells. 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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Mesenchymal Stem Cells Mesenchymal Stem Cells Mesenchymal Stem Cells Mesenchymal Stem Cells Mesenchymal Stem Cells Mesenchymal Stem Cells Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency

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