Mesenchymal Stromal Cells Support Endometriotic Stromal CellsIn Vitro

Fawaz Abomaray, Sebastian Gidlöf, Bartosz Bezubik, Mikael Engman, Cecilia Götherström
Stem cells international · 2018 · vol. 2018 , pp. 1–12 · doi:10.1155/2018/7318513 · PMID:29535779 · W2787076351
article OA: gold CC0 ⤵ 9 in-corpus citations
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Allogeneic mesenchymal stromal cells increased proliferation, survival, and tube formation of endometriosis-derived stromal cells, suggesting they support the disease rather than offer a therapeutic benefit.

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Abstract

Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells. Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases. Therefore, the aim herein was to examine effects of allogeneic MSC on endometriosis-derived cells in vitro as a potential therapy for endometriosis. MSC from allogeneic adipose tissue (Ad-MSC) and stromal cells from endometrium (ESC endo ) and endometriotic ovarian cysts (ESC cyst ) from women with endometriosis were isolated. The effects of Ad-MSC on ESC endo and ESC cyst were investigated using in vitro proliferation, apoptosis, adhesion, tube formation, migration, and invasion assays. Ad-MSC significantly increased proliferation of ESC compared to untreated controls. Moreover, Ad-MSC significantly decreased apoptosis and increased survival of ESC. Ad-MSC significantly increased adhesion of ESC endo and not ESC cyst on fibronectin. Conditioned medium from cocultures of Ad-MSC and ESC significantly increased tube formation of human umbilical vein endothelial cells on matrigel. Ad-MSC may significantly increase migration of ESC cyst and did not increase invasion of both cell types. The data suggest that allogeneic Ad-MSC should not be considered as a potential therapy for endometriosis, because they may support the pathology by maintaining and increasing growth of ectopic endometrial tissue.

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endometriosis

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