The long road of drug development for endometriosis – Pains, gains, and hopes

Condition tags

MeSH descriptors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

• Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis via openalex
• Actuarial Analysis of Private Payer Administrative Claims Data for Women With Endometriosis via openalex
• Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex
• A long-acting anti–IL-8 antibody improves inflammation and fibrosis in endometriosis via openalex
• Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility via openalex
• A Modified Baboon Model for Endometriosis via openalex
• Anastrazole and oral contraceptives: a novel treatment for endometriosis via openalex
• Angiogenic properties of endometrial mesenchymal stromal cells in endothelial co-culture: an in vitro model of endometriosis via openalex
• Animal models of endometriosis: Replicating the aetiology and symptoms of the human disorder via openalex
• A novel homologous model for noninvasive monitoring of endometriosis progression† via openalex
• Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target via openalex
• Aromatase as a Therapeutic Target in Endometriosis via openalex
• Assessing research gaps and unmet needs in endometriosis via openalex
• Assessment of TET1 gene expression, DNA methylation and H3K27me3 level of its promoter region in eutopic endometrium of women with endometriosis and infertility via openalex
• Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis via openalex
• Cancer-Associated Mutations in Endometriosis without Cancer via openalex
• Central changes associated with chronic pelvic pain and endometriosis via openalex
• Characterization of human purified epithelial and stromal cells from endometrium and endometriosis in tissue culture via openalex
• CHC for pelvic pain in women with endometriosis: ineffectiveness or discontinuation due to side-effects via openalex
• Clinical diagnosis of endometriosis: a call to action via openalex
• Clinical Management of Endometriosis via openalex
• Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium via openalex
• Clonogenicity of Human Endometrial Epithelial and Stromal Cells1 via openalex
• Coelomic Metaplasia Theory of Endometriosis: Evidence from in vivo Studies and an in vitro Experimental Model via openalex
• Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells via openalex
• Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex
• Complex genetics of female fertility via openalex
• Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen via openalex
• Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis via openalex
• Diagnostic delay in women with pain and endometriosis via openalex
• Diagnostic Delay of Endometriosis in the Netherlands via openalex
• Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies—A Systematic Review via openalex
• Do endometriomas induce an inflammatory reaction in nearby follicles? via openalex
• Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex
• Effects of histone methyltransferase inhibition in endometriosis† via openalex
• Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment via openalex
• Endometrial stem/progenitor cells in menstrual blood and peritoneal fluid of women with and without endometriosis via openalex
• Endometriosis via openalex
• Endometriosis and IVF treatment outcomes: unpacking the process via openalex
• Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat via openalex
• Endometriosis-associated chronic pelvic pain via openalex
• Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex
• Endometriosis-associated infertility: From pathophysiology to tailored treatment via openalex
• Endometriosis organoids: prospects and challenges via openalex
• Endometriosis: pathogenesis and treatment via openalex
• Endometriosis research: animal models for the study of a complex disease via openalex
• Endometriosis: The Role of Neuroangiogenesis via openalex
• Endometriotic inflammatory microenvironment induced by macrophages can be targeted by niclosamide† via openalex
• Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis via openalex
• Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes via openalex
• Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli via openalex
• Establishment of Immortalized Human Endometriotic Stromal Cell Line from Ectopic Lesion of a Patient with Endometriosis via openalex
• Evaluation of PLGA containing anti -CTLA4 inhibited endometriosis progression by regulating CD4 + CD25 + Treg cells in peritoneal fluid of mouse endometriosis model via openalex
• Evaluation of two endometriosis models by transplantation of human endometrial tissue fragments and human endometrial mesenchymal cells via openalex
• Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes via openalex
• Genetic influences on endometriosis in an Australian twin sample via openalex
• Genome‐wide analysis of DNA methylation in endometriosis using Illumina Human Methylation 450 K BeadChips via openalex
• Genome-Wide Association Study Link Novel Loci to Endometriosis via openalex
• Global, regional, and national endometriosis trends from 1990 to 2017 via openalex
• Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex
• High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex
• Iatrogenic endometriosis harbors somatic cancer-driver mutations via openalex
• Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex
• Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis via openalex
• Implantation Failure in Endometriosis Patients: Etiopathogenesis via openalex
• Incidence of endometriosis by study population and diagnostic method: the ENDO study via openalex
• Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3′,5′-Cyclic Adenosine 5′-Monophosphate Inhibition of Cyclin D1 via openalex
• Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis via openalex
• Induced Endometriosis in Nonhuman Primates1 via openalex
• Inflammatory Mediators and Pain in Endometriosis: A Systematic Review via openalex
• Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis via openalex
• Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis via openalex
• Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin via openalex
• Initial Endometriosis Showing Direct Morphologic Evidence of Metaplasia in the Pathogenesis of Ovarian Endometriosis via openalex
• Innervation of ectopic endometrium in a rat model of endometriosis via openalex
• Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis via openalex
• Isolation and purification of human endometrial stromal and glandular cells using immunomagnetic microspheres via openalex
• Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. via openalex
• Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex
• Local activation of TGF-beta1 at endometriosis sites. via openalex
• Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial via openalex
• Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex
• Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis via openalex
• MAPK/ERK signal pathway involved expression of COX-2 and VEGF by IL-1β induced in human endometriosis stromal cells in vitro. via openalex
• MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis? via openalex
• Mesenchymal Stromal Cells Support Endometriotic Stromal Cells<i>In Vitro</i> via openalex
• Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. via openalex
• Modeling the early endometriotic lesion: mesothelium-endometrial cell co-culture increases endometrial invasion and alters mesothelial and endometrial gene transcription via openalex
• Nonhuman Primate Models for Translational Research in Endometriosis via openalex
• Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex
• Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2) via openalex
• Oral contraceptives for pain associated with endometriosis via openalex
• Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
• Pathogenesis of endometriosis via openalex
• Pathophysiology, diagnosis, and management of endometriosis via openalex
• Possible Pathophysiological Roles of Mitogen‐Activated Protein Kinases (MAPKs) in Endometriosis via openalex
• Pregnancy outcomes in women with endometriosis and/or ART use: a population-based cohort study via openalex
• Protein kinase inhibitors can control the progression of endometriosis <i>in vitro</i> and <i>in vivo</i> via openalex
• Reevaluating response and failure of medical treatment of endometriosis: a systematic review via openalex
• Research advances in endometriosis-related signaling pathways: A review via openalex

Cited by (4)

• Is Recurrent Endometriosis a Reprogrammed Disease? Molecular Persistence Beyond Surgical Clearance 2026
• Personalized approach to infertility treatment in endometriosis: results of a prospective cohort study 2025
• Novel discovery of geraniol and salvianolic acid B in regulating endometriosis recurrence targets LGALS3/VEGFA via integrating AI and biosensors 2025
• Beyond one-size-fits-all: single-cell transcriptomic signatures predict drug efficacy and reveal responder subgroups in endometriosis 2025

Source provenance

europepmc

last seen: 2026-06-04T01:30:01.192114+00:00

openalex

last seen: 2026-06-10T17:14:06.276822+00:00

pmc

last seen: 2026-05-13T20:22:03.195721+00:00

pubmed

last seen: 2026-06-04T00:32:22.903660+00:00