Aromatase as a therapeutic target in endometriosis

S E Bulun, Bulun Se, Serdar E. Bulun, Zeitoun KM, Khaled Zeitoun, K M Zeitoun, Takayama K, K Takayama, Kazuto Takayama, Evan R. Simpson, Simpson E, E Simpson, Sasano H, Hironobu Sasano, H Sasano
Trends in endocrinology and metabolism: TEM · 2000 · vol. 11(1) , pp. 22–27 · doi:10.1016/s1043-2760(99)00216-7 · PMID:10652502 · W2002433119
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This paper investigates aromatase as a potential therapeutic target for endometriosis, exploring its role in the disease and potential treatment strategies.

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Abstract

In contrast to normal endometrium, the expression of aromatase is aberrant in endometriosis and is stimulated by prostaglandin E2 (PGE2). This results in local production of estrogen, which induces PGE2 formation and establishes a positive feedback cycle. Another abnormality in endometriosis--deficient 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) type 2 expression--impairs the inactivation of estradiol (E2) to estrone (E1). These molecular aberrations collectively favor accumulation of increasing quantities of E2, and PGE2 in endometriosis. The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis with an aromatase inhibitor.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Aromatase Endometriosis Endometriosis Aromatase Aromatase Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

Cited by (31)

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