Evan R. Simpson — Endo Lab

article 2016

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

·doi:10.1016/j.lfs.2016.06.022

AimsControversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies addressing this question do not distinguish between direct effects of estrogen and indirect activation of estrogen…

review 2008

Aromatase expression in women's cancers

Advances in experimental medicine and biology ·doi:10.1007/978-0-387-78818-0_8

Estrogen has been positively linked to the pathogenesis and growth of three common women's cancers (breast, endometrium and ovary). A single gene encodes the key enzyme for estrogen biosynthesis named aromatase, inhibition of which effectiv…

article 2002

Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.7.8683

Aromatase P450 (P450arom) is the key enzyme for the biosynthesis of estrogen that is essential for the growth of human endometriosis, a pathology characterized by endometrium-like tissue on the peritoneal surfaces of abdominal organs manife…

review 2000

Aromatase as a Therapeutic Target in Endometriosis

Trends in endocrinology and metabolism: TEM ·doi:10.1016/s1043-2760(99)00216-7

In contrast to normal endometrium, the expression of aromatase is aberrant in endometriosis and is stimulated by prostaglandin E2 (PGE2). This results in local production of estrogen, which induces PGE2 formation and establishes a positive …