Alternative Therapieoptionen bei Endometriose

In: Der Gynäkologe · 2007 · vol. 40(7) , pp. 553–558 · doi:10.1007/s00129-007-2016-5 · W1485762110
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Devil's Claw root extract, a phytopharmaceutical, shows anti-inflammatory and analgesic effects by inhibiting inflammatory mediators and prostaglandin E2, suggesting it as a primary endometriosis therapy option.

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The paper discusses the problem of treating endometriosis, noting that traditional therapies are associated with high relapse rates and side effects, and therefore reviews the growing role of alternative phytopharmaceutical approaches. It highlights devil’s claw root (Harpagophytum procumbens) extracts as an example, describing evidence that they inhibit biosynthesis of inflammatory mediators including cytokines, leukotrienes, thromboxane, and prostaglandin E2. The authors frame these anti-inflammatory and analgesic effects as supporting devil’s claw extracts as a potential primary therapy option for endometriosis when indications are carefully selected, while the approach is presented in the context of practical therapy concepts rather than as a single clinical trial. This paper is centrally about endometriosis — it focuses on alternative phytopharmaceutical therapy options, especially devil’s claw extracts, for endometriosis-related complaints.

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Zusammenfassung Die Behandlung der Endometriose stellt den Kliniker vor zahlreiche Probleme. Klassische Therapieoptionen sind durch eine hohe Rezidiv- und Nebenwirkungsrate charakterisiert. Deshalb finden zunehmend alternative Behandlungsmöglichkeiten, wie die Applikation von Phytopharmaka, Eingang in praktische Therapiekonzepte. Die alternativen Therapiekonzepte werden von den betroffenen Frauen als wirkungsvolle Ergänzung zur „klassischen“ Endometriosetherapie empfunden. Bei der Behandlung von endometriosebedingten Beschwerden ist dabei die Applikation von Extrakten der Teufelskrallenwurzel – Harpagophytum procumbens – hervorzuheben. Dieses Phytopharmakon hemmt nachweislich die Biosynthese der Entzündungsmediatoren Zytokine, Leukotriene und Thromboxan sowie die Bildung des Prostaglandin E2. Durch diese antiphlogistische und analgetische Wirkung können Teufelskrallenextrakte bei richtiger Indikationsstellung eine primäre Therapieoption bei der Endometriose bedeuten. Abstract The treatment of endometriosis presents the clinician with a host of problems. Traditional therapy options are followed by a high relapse rate and produce a wide range of side effects. For this reason, alternative methods of treatment, such as the application of phytopharmaceuticals, are steadily gaining ground in practical therapy concepts. These alternative therapy options are rated by affected women as an effective complement to “classic” endometriosis therapy. In the treatment of endometriosis-related ailments the application of extracts of Devil’s Claw root – Harpagophytum procumbens – merits special mention. This phytopharmaceutical has been shown to inhibit the biosynthesis of the inflammatory factors – cytokines, leukotrines and thromboxane – and also the production of prostaglandin E2. Because of these anti-inflammatory and analgesic effects, Devil’s Claw extracts can be regarded as a primary therapy option for endometriosis for carefully selected indications. 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Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Arndt, D., Bobermien, K., Heyer, H. et al. Alternative Therapieoptionen bei Endometriose. Gynäkologe 40, 553–558 (2007). https://doi.org/10.1007/s00129-007-2016-5 Published: Issue date: DOI: https://doi.org/10.1007/s00129-007-2016-5

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