Use of estrogen antagonists and aromatase inhibitors in endometriosis.
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Abstract
Endometriosis is an estrogen-dependent disorder mostly occurring in reproductive-age women. Various therapies have been used in an attempt to treat endometriosis, including ovarian suppression therapy, surgical treatment or a combination of these strategies. However, in general, substantial surgery remains the primary treatment option for endometriosis at all stages. Recently, aromatase inhibitors and anti-estrogens have been proposed as novel potential candidates. The rationale for the use of aromatase inhibitors is mostly related to the high aromatase expression in endometriotic cysts and extra-ovarian endometriotic implants. Among anti-estrogens, raloxifene has been investigated in animal models with good results, but in premenopausal women, the compound does not seem to suppress estrogen production.
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Cited by (22)
- A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date 2023
- Pharmacology of Endometriosis 2021
- Predictive Biomarkers May allow Precision Therapy of Endometriosis 2017
- Use of aromatase inhibitors in practice of gynecology 2015
- The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety 2015
- Anti-TNF-α treatment for pelvic pain associated with endometriosis 2013
- Progesterone Resistance, Aromatase, and Inflammation: The Important Relationships Between Hormones and Inflammation 2012
- Pentoxifylline for endometriosis 2012
- Activation of mutated K‐ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis 2011
- Anti-TNF-α treatment for pelvic pain associated with endometriosis 2010
- Anti-TNF-α treatment for pelvic pain associated with endometriosis 2009
- Pentoxifylline versus medical therapies for subfertile women with endometriosis 2009
- Pentoxifylline versus medical therapies for subfertile women with endometriosis 2009
- Endometriosis 2009
- Inflammation in the uterus induces phosphorylated extracellular signal‐regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats 2008
- Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis 2008
- Alternative Therapieoptionen bei Endometriose 2007
- Der derzeitige Stand der konservativen Therapie der Endometriose 2006
- Subcutaneous Depot Medroxyprogesterone Acetate versus Leuprolide Acetate in the Treatment of Endometriosis-Associated Pain 2006
- Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: New questions—old answers? 2005
- Advances in the management of endometriosis: an update for clinicians 2005
- Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain 2005
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