Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman

Sandro Razzi, Antonio Fava, Annalisa Sartini, Simona De Simone, Simona Simone, Luigi Cobellis, Felice Petraglia
BJOG: An International Journal of Obstetrics & Gynaecology · 2004 · vol. 111(2) , pp. 182–184 · doi:10.1046/j.1471-0528.2003.00038.x · PMID:14723761 · W2033387004
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This case report details the successful treatment of severe recurrent endometriosis in a young ovariectomized woman using an aromatase inhibitor to reduce estrogen levels.

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Abstract

Endometriosis is a chronic and progressive disease manifested by chronic pelvic pain and infertility and which may affect 2–10% of women of reproductive age. Because it is an oestrogen-dependent disease, the goal of current medical therapy is to induce hypoestrogenism or to antagonise oestrogen action. Oestrogen biosynthesis in women of reproductive age takes place primarily in the ovary, while after spontaneous or surgical menopause, the adipose tissue and adrenal glands are the main source.1 Aromatase P450 catalyses the conversion of androstenedione of adrenal origin to oestrogens, endometriotic tissues express it2–4 and prostaglandins are the most potent known aromatase stimulator in endometriotic stromal cells.

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Condition tags

dyspareuniaendometriosischronic_pelvic_paininfertility

MeSH descriptors

Aromatase Inhibitors Endometriosis Enzyme Inhibitors Nitriles Ovarian Diseases Peritoneal Diseases Triazoles Administration, Oral Adult Dyspareunia Dyspareunia Endometriosis Enzyme Inhibitors Female Humans Letrozole Nitriles Ovarian Diseases Ovariectomy Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (50)

Source provenance

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