Drug therapy in the treatment of endometriosis

А.А. Popov, B. A. Slobodyanyuk, Т. Н. Мананникова, А.А. Fedorov, T. Z. Chanturia, S. I. Zingan
In: Medical Council · 2016 · pp. 86–91 · doi:10.21518/2079-701x-2016-2-86-91 · W2296189379
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews medical and surgical treatment options for endometriosis, a chronic disease requiring lifelong management tailored to individual patients to maximize medical therapy and minimize surgery.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper reviews drug therapy options for endometriosis, discussing hormonal and non-hormonal approaches and the evidence base behind them, including NSAIDs, progestins such as dienogest, GnRH agonists like leuprolide with add-back therapy, and other agents such as aromatase inhibitors, anti-TNF therapies, and pentoxifylline. Across the referenced studies, the key finding is that multiple pharmacologic classes have been evaluated for pain and recurrence outcomes, with evidence drawn from clinical trials and systematic reviews cited in the paper’s bibliography. The authors’ major limitation is that it is a literature/review-style article rather than an original controlled study, so conclusions depend on the quality and heterogeneity of included sources. This paper is centrally about endometriosis — it is a narrative review of drug therapy approaches for treating endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Clinical studies of medicine-based and surgical methods for the treatment of endometriosis are described. Although endometriosis was described as early as in the XIX century, the causes for its emergence and spread have not been fully investigated. Also, many questions regarding methods of treatment remain far from being solved. Due to the chronic and often relapsing nature of the disease, Practice Committee of the American Society for Reproductive Medicine (ASRM) has concluded the following: "endometriosis should be viewed as a chronic disease that requires a lifelong management plan with the goal of maximizing the use of medical treatment and avoiding repeated surgical procedures." Thus, treatment of endometriosis should not only be comprehensive but also adapted to the specifics of each woman's organism.
Full text 7,267 characters · extracted from oa-doi-fallback · click to expand
Медикаментозная терапия в лечении эндометриоза https://doi.org/10.21518/2079-701X-2016-2-86-91 Аннотация Об авторах А. А. ПоповРоссия Б. А. Слободянюк Россия Т. Н. Мананникова Россия А. А. Федоров Россия Т. З. Чантурия Россия Ш. И. Зинган Россия Список литературы 1. Holoch KJ., Lessey B.A. Endometriosis and infertility. Clin. Obstet. Gynecol., 2010, 53(2): 429-438. 2. Practice Committee of American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis. Fertil. Steril., 2008, 90: 260. 3. Попов А.А., Слободянюк Б.А., Мананникова Т.Н. и соавт. Медикаментозная терапия в лечение эндометриоза, РМЖ, 2014, 14, 1010. 4. Kennedy S., Bergqvist A., Chapron C. et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum. Reprod., 2005, 20(10): 2698-2704. 5. Allen C, Hopewell S, Prentice A, Gregory D. Nonsteroidal antiinflammatory drugs for pain in women with endometriosis. Cochrane Database Syst. Rev. 2009. Vol. 2:CD004753. 6. Vercellini P, Eskenazi B, Consonni D et al. Oral contraceptives and risk of endometriosis: A systematic review and meta-analysis. Hum. Reprod. Update, 2011, 17(2): 159-170. 7. Telimaa S, Puolakka J, Ronnberg L, Kauppila A. Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis. Gynecol. Endocrinol, 1987, 1(1): 13-23. 8. Barbieri RL, Evans S, Kistner RW. Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up. Fertil. Steril., 1982, 37: 737. 9. Selak V, Farquhar C, Prentice A, Singla A. Danazol for pelvic pain associated with endo-metriosis // Cochrane Database Syst. Rev. 2007. :CD000068. 10. Muneyyirci-Delale O, Karacan M. Effect of nore-thindrone acetate in the treatment of symptomatic endometriosis. Int. J. Fertil. Womens Med., 1998, 43(1): 24-27. 11. Sasagawa S, Shimizu Y, Kami H et al. Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile. Steroids, 2008, 73(2): 222-231. 12. Sasagawa S, Shimizu Y, Nagaoka T et al. Dienogest, a selective progestin, reduces plasma estradiol level through induction of apop-tosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys. J. Endocrinol. Invest, 2008, 31(7): 636-641. 13. Mueck AO. What makes dienogest a unique progestogen for the treatment of endometrio-sis? Gynaecol. Forum, 2010, 15(2): 18-23. 14. Katayama H, Katayama T, Uematsu K et al. Effect of dienogest administration on angio-genesis and hemodynamics in a rat endometri-al autograft model. Hum. Reprod, 2010, 25(11): 2851-2858. 15. Strowitzki T, Faustmann T, Gerlinger C, Seitz C. Dienogest in the treatment of endometriosis associated pelvic pain: a 12 week, randomized, double blind, placebo controlled study. Eur. J. Obstet. Gynecol. Reprod. Biol., 2010, 151: 193-198. 16. McCormack PL. Dienogest: a review of its use in the treatment of endometriosis. Drugs, 2010, 70: 2073-2088. 17. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24 week, randomized, multicentre, openlabel trial. Hum. Reprod, 2010, 25: 633-641. 18. Strowitzki T, et al. Eur J Obstet Gynecol Reprod Biol, 2010, 151: 193-198. Petraglia F, et al. Arch Gynecol Obstet, 2012, 285: 167-173. 19. Ota Y, Kurashiki, Japan. Postoperative treatments with progestins and prevention of endo-metriosis recurrence: effectiveness of dien-ogest and combined oral contraceptives (COCs), VIII International Congress on Reproductive Medicine, Jan, 2014. 20. Guzick DS, Huang LS, Broadman BA et al. Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain. Fertil. Steril, 2011, 95: 1568. 21. Hornstein MD, Surrey ES, Weisberg GW, Casino LA. Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group. Obstet. Gynecol, 1998, 91: 16. 22. Hurst BS, Gardner SC, Tucker KE et al. Delayed oral estradiol combined with leuprolide increases endometriosis-related pain. JSLS, 2000, 4: 97. 23. Surrey ES, Hornstein MD. Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up. Obstet. Gynecol, 2002, 99: 709. 24. Kitawaki J, Kusuki I, Yamanaka K, Suganuma I. Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain. Eur. J. Obstet. Gynecol. Reprod. Biol., April 5, 2011. 25. Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometri-osis? Fertil. Steril, 2006, 85: 1307. 26. Razzi S, Fava A, Sartini A et al. Treatment of severe recurrent endometriosis with an aro-matase inhibitor in a young ovariectomised woman. BJOG, 2004, 111: 182. 27. Takayama K, Zeitoun K, Gunby RT et al. Treatment of severe postmenopausal endome-triosis with an aromatase inhibitor. Fertil. Steril., 1998, 69: 709. 28. Ailawadi RK, Jobanputra S, Kataria M et al. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil. Steril, 2004, 81: 290. 29. Shippen ER, West WJ. Jr. Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor. Fertil. Steril, 2004, 81: 1395. 30. Amsterdam LL, Gentry W, Jobanputra S et al. Anastrazole and oral contraceptives: a novel treatment for Endometriosis. Fertil. Steril, 2005, 84: 300. 31. Hefler LA, Grimm C, van Trotsenburg M, Nagele F. Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study. Fertil. Steril, 2005, 84: 1033. 32. Fatemi HM, Al-Turki HA, Papanikolaou EG. et al. Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor. Reprod. Biomed. Online, 2005, 11: 455. 33. Soysal S, Soysal ME, Ozer S et al. The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial. Hum. Reprod, 2004, 19: 160. 34. Nawathe A, Patwardhan S, Yates D et al. Systematic review of the effects of aromatase inhibitors on pain associated with endometrio-sis. BJOG, 2008, 115: 818. 35. Lu D, Song H, Shi G. Anti-TNF-а treatment for pelvic pain associated with endometriosis. Cochrane Database Syst. Rev. 2013; 3: CD008088. 36. Lu D, Song H, Li Y et al. Pentoxifylline for endometriosis. Cochrane Database Syst. Rev., 2012, 1:CD007677. 37. Popov A.A., Slobodyanyuk B.A., Manannikova T.N. et al. Medicine-based therapy in the treatment of endometriosis, RMZ, 2014, 14, 1010. Рецензия Для цитирования: Попов АА, Слободянюк БА, Мананникова ТН, Федоров АА, Чантурия ТЗ, Зинган ШИ. Медикаментозная терапия в лечении эндометриоза. Медицинский Совет. 2016;(2):86-91. https://doi.org/10.21518/2079-701X-2016-2-86-91 For citation: Popov AA, Slobodyanyuk BA, Manannikova TN, Fedorov AA, Chanturia TZ, Zingan SI. Drug therapy in the treatment of endometriosis. Meditsinskiy sovet = Medical Council. 2016;(2):86-91. (In Russ.) https://doi.org/10.21518/2079-701X-2016-2-86-91 JATS XML

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK