Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model
article
OA: closed
CC0
⤵ 53 in-corpus citations
AI-generated summary
Dienogest administration suppressed angiogenesis in a rat endometrial autograft model, reducing microvascular network size and density, while altering microvessel structure and perivascular smooth muscle actin levels.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
BACKGROUND: We aimed to establish an endometrial autograft model in rats that would allow for repetitive in vivo analyses of angiogenesis. Dienogest (DNG) is an orally active progestin used for the treatment of endometriosis. We investigated whether DNG would affect angiogenesis of the ectopic endometrium in our model. METHODS: Mechanically isolated endometrial fragments were transplanted into dorsal skinfold chambers in rats. We analyzed the effect of DNG on angiogenesis of the ectopic endometrium on Days 0, 2, 4, 7, 10 and 14 after transplantation using intravital fluorescence microscopy. RESULTS: The DNG-administered group showed significant suppression of angiogenesis of endometrial autografts, as indicated by the reduced size of the microvascular network and decreased microvessel density compared with those of control animals. The newly formed microvessels of the DNG-administered group showed consistently elevated diameters and centerline red blood cell velocity was decreased. Immunohistochemistry revealed a significant reduction in the level of perivascular α-smooth muscle actin within endometrial grafts of the DNG-administered group. CONCLUSIONS: DNG inhibited angiogenesis of the ectopic endometrium, with confirmed structural changes in the microvessels.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (41)
- A functional model for progestogen-induced breakthrough bleeding via openalex
- Angiongenesis: a new theory for endometriosis via openalex
- Antiangiogenic Agents Are Effective Inhibitors of Endometriosis via openalex
- Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions via openalex
- Danazol for pelvic pain associated with endometriosis via openalex
- Diagnosis and management of endometriosis. via openalex
- Dienogest via openalex
- Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex
- Endometriosis and infertility via openalex
- Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women via openalex
- ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
- Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues via openalex
- Influence of Dienogest on Ovulation in Young Fertile Women via openalex
- In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy via openalex
- Medical and Surgical Therapies for Pain Associated with Endometriosis via openalex
- Modern combined oral contraceptives for pain associated with endometriosis via openalex
- Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
- Perivascular smooth muscle -actin is reduced in the endometrium of women with progestin-only contraceptive breakthrough bleeding via openalex
- Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex
- Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model via openalex
- Progestogens for endometriosis: forward to the past via openalex
- Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation via openalex
- Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis via openalex
- Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex
- Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex
- The expression of vascular endothelial growth factor isoforms in cultured human endometrial stromal cells and its regulation by 17beta- oestradiol via openalex
- The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro via openalex
- Treatment of Endometriosis via openalex
- W1968316164 via openalex
- W2322133447 via openalex
- W1565679163 via openalex
- W4232297333 via openalex
- W2002687754 via openalex
- W2079190330 via openalex
- W2100281208 via openalex
- W2101417341 via openalex
- W2034864360 via openalex
- W2126728673 via openalex
- W2132050566 via openalex
- W2055280382 via openalex
- W2159738525 via openalex
Cited by (50)
- High inhibition ratio and transformation index of 2 mg dienogest: further evidence for its use in endometriosis treatment 2025
- Clinical efficacy of dienogest against endometriomas with a maximum diameter of ≥4 cm 2024
- Endometriosis as a risk factor for ovarian cancer: an update on screening, risk reduction, treatment and prognosis 2024
- Immunologic Aspects of Endometriosis 2024
- Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model 2023
- iRGD-Targeted Peptide Nanoparticles for Anti-Angiogenic RNAi-Based Therapy of Endometriosis 2023
- Spontaneous recurrent menstrual pneumothorax: a case report 2023
- Polycondensed Peptide-Based Polymers for Targeted Delivery of Anti-Angiogenic siRNA to Treat Endometriosis 2023
- ENDOMETRİOZ 2023
- Progesterone Resistance in Endometriosis: Current Evidence and Putative Mechanisms 2023
- Efficacy and Safety of Dienogest in the Management of Women with Endometriosis; Systematic Review and Meta-Analysis 2023
- Segmented in vitro fertilization and frozen embryo transfer in dienogest-treated patient with adenomyosis: A case report and lierature review 2022
- Systematic review and Meta-analysis of efficacy and safety of dienogest in treatment of endometriosis 2021
- Use of dopamine agonists to target angiogenesis in women with endometriosis 2020
- Main line of hormonal therapy and hormonal prevention of endometriosis at present stage of medicine development 2020
- Comparison of dienogest effects upon 3,3′–diindolylmethane supplementation in models of endometriosis and clinical cases 2018
- Comparative assessment of effectiveness of new drugs for targeted therapy of endometriosis by experimental model 2018
- Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis 2018
- Basic mechanisms of vascularization in endometriosis and their clinical implications 2018
- Dienogest-The Millennium Molecule!! 2018
- Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside 2017
- Effect of Genistein, Leuprolide Acetate and Dienogest towards Progesterone Receptor, IL-8, MMP-2 Expression of Lesions in a Peritoneal Mice Model of Endometriosis 2017
- Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills 2017
- Short-term histopathological effects of dienogest therapy on ovarian endometriomas: <i>in vivo</i>, nonrandomized, controlled trial 2017
- Dienogest for Treatment of Endometriosis in Chinese Women: A Placebo-Controlled, Randomized, Double-Blind Phase 3 Study 2017
- Dienogest - The Millennium Molecule!! 2017
- Is endometriosis a benign disease? Modern controversial aspects of endometriosis-associated ovarian tumors 2016
- Drug therapy in the treatment of endometriosis 2016
- The experience of Visanne use in patients of reproductive age with external genital endometriosis 2016
- Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis 2016
- Does dienogest influence the inflammatory response of endometriotic cells? A systematic review 2015
- Progestin Therapy in Endometriosis 2015
- Development of a mouse model for testing therapeutic agents: the anticancer effect of dienogest on endometrial neoplasms 2015
- Pelvic Pain and Quality of Life of Women With Endometriosis During Quadriphasic Estradiol Valerate/Dienogest Oral Contraceptive: A Patient-Preference Prospective 24-Week Pilot Study 2014
- Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system 2014
- Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis 2014
- Literature Review on Biological Effects of against Gynaecological Diseases 2013
- Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment 2013
- Effects of<i>Lactobacillus gasseri</i>OLL2809 on the Induced Endometriosis in Rats 2013
- Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review) 2012
- Anti-angiogenic treatment strategies for the therapy of endometriosis 2012
- Female Infertility and Free Radicals: Potential Role in Endometriosis and Adhesions 2012
- Progesterone Resistance and Targeting the Progesterone Receptors: A Therapeutic Approach to Endometriosis 2012
- New developments in oral contraception: clinical utility of estradiol valerate/dienogest (Natazia&reg;) for contraception and for treatment of heavy menstrual bleeding: patient considerations 2012
- Treatment of endometriosis in different ethnic populations: a meta-analysis of two clinical trials 2012
- Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis 2012
- The current place of progestins in the treatment of endometriosis 2012
- Dienogest in long-term treatment of endometriosis 2011
- Dienogest (DNG) in der Therapie der Endometriose Übersicht zur aktuellen Studienlage 2011
- Ovulation‐Inhibiting Effects of Dienogest in a Randomized, Dose‐Controlled Pharmacodynamic Trial of Healthy Women 2011
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:17:00.782903+00:00
License: CC0
· commercial use OK