Does dienogest influence the inflammatory response of endometriotic cells? A systematic review

Giovanni Grandi, Michael Mueller, Mueller M, Michael D. Mueller, Nick A. Bersinger, Bersinger NA, Angelo Cagnacci, Annibale Volpe, Volpe A, Brett McKinnon
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015 · vol. 65(3) , pp. 183–192 · doi:10.1007/s00011-015-0909-7 · PMID:26650031 · W2191296080
review OA: green CC0 ⤵ 51 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-13 ⓘ

This paper investigates whether dienogest influences the inflammatory response of endometriotic cells through a systematic review.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

The content provided does not include the actual systematic review text, methods, included studies, or reported findings; instead, it shows a server anti-bot interstitial requiring JavaScript (Anubis), which prevents access to the paper’s details. Because the study results and stated limitations are not visible, I cannot accurately summarize what the review analyzed about dienogest and inflammatory responses in endometriotic cells. The paper does appear to be titled as a systematic review on whether dienogest influences the inflammatory response of endometriotic cells, but no substantive content is available to confirm or describe its key findings or caveats. This paper is centrally about endometriosis — it is a systematic review specifically addressing dienogest effects on inflammatory responses in endometriotic cells.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective and designA systematic review of all literature was done to assess the ability of the progestin dienogest (DNG) to influence the inflammatory response of endometriotic cells.Main outcome measuresIn vitro and in vivo studies report an influence of DNG on the inflammatory response in eutopic or ectopic endometrial tissue (animal or human).ResultsAfter strict inclusion criteria were satisfied, 15 studies were identified that reported a DNG influence on the inflammatory response in endometrial tissue. These studies identified a modulation of prostaglandin (PG) production and metabolism (PGE2, PGE2 synthase, cyclo-oxygenase-2 and microsomal PGE synthase-1), pro-inflammatory cytokine and chemokine production [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, monocyte chemoattractant protein-1 and stromal cell-derived factor-1], growth factor biosynthesis (vascular endothelial growth factor and nerve growth factor) and signaling kinases, responsible for the control of inflammation. Evidence supports a progesterone receptor-mediated inhibition of the inflammatory response in PR-expressing epithelial cells. It also indicated that DNG inhibited the inflammatory response in stromal cells, however, whether this was via a PR-mediated mechanism is not clear.ConclusionsDNG has a significant effect on the inflammatory microenvironment of endometriotic lesions that may contribute to its clinical efficacy. A better understanding of the specific anti-inflammatory activity of DNG and whether this contributes to its clinical efficacy can help develop treatments that focus on the inhibition of inflammation while minimizing hormonal modulation.
Full text 1,068 characters · extracted from oa-html · click to expand
Making sure you're not a bot! Loading... You are seeing this because the administrator of this website has set up Anubis to protect the server against the scourge of AI companies aggressively scraping websites. This can and does cause downtime for the websites, which makes their resources inaccessible for everyone. Anubis is a compromise. Anubis uses a Proof-of-Work scheme in the vein of Hashcash, a proposed proof-of-work scheme for reducing email spam. The idea is that at individual scales the additional load is ignorable, but at mass scraper levels it adds up and makes scraping much more expensive. Ultimately, this is a placeholder solution so that more time can be spent on fingerprinting and identifying headless browsers (EG: via how they do font rendering) so that the challenge proof of work page doesn't need to be presented to users that are much more likely to be legitimate. Please note that Anubis requires the use of modern JavaScript features that plugins like JShelter will disable. Please disable JShelter or other such plugins for this domain.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunologic Factors Nandrolone Animals Cytokines Cytokines Endometriosis Epithelial Cells Epithelial Cells Epithelial Cells Female Hormone Antagonists Hormone Antagonists Humans Immunologic Factors Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins Nandrolone Nandrolone Prostaglandins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (50)

Source provenance

europepmc
last seen: 2026-09-06T09:34:12.023084+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:33.600579+00:00
License: CC0 · commercial use OK