Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum

Dominic Bertschi, Brett D McKinnon, Brett McKinnon, Jakob Evers, Nick A Bersinger, Michael D Mueller
Mediators of inflammation · 2013 · vol. 2013 , pp. 1–7 · doi:10.1155/2013/450950 · PMID:24453419 · W2127874042
article OA: gold CC0 ⤵ 24 in-corpus citations
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Endometriotic lesions from the rectovaginal septum showed significantly higher expression of inflammatory chemokines ENA-78 and RANTES, and cytokines IL-6 and TNF α compared to matching eutopic tissue and lesions from ovaries or peritoneum.

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Abstract

Endometriosis is characterised by the growth of ectopic lesions at multiple locations outside the uterine cavity and may be considered a collection of distinct but related conditions. The exact aetiology of endometriosis is still not clear although a role for inflammation is increasingly accepted. We therefore investigated the inflammatory activity of eutopic tissue and that of the matching ectopic lesions from different locations by measuring the genetic expression of inflammatory chemokines and cytokines. The gene expression in matching eutopic and ectopic tissue was compared, as was the gene expression in lesions from different locations. A significantly higher mRNA expression of the chemokines ENA-78 and RANTES and the cytokines IL-6 and TNF α was observed in endometriotic lesions of the rectovaginal septum (RVS) compared to that of matching eutopic tissue. Comparisons across lesion locations showed a significantly higher expression of IL-6 and TNF α in the RVS compared to lesions from either the ovaries or the peritoneum. These results show that the production of some inflammatory chemokines and cytokines is significantly increased in the ectopic endometrial tissue compared to matching eutopic tissue. Furthermore, IL-6 and TNF α are produced in significantly higher quantities in RVS lesions compared to other lesions.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Inflammation Vagina Adult Chemokine CCL5 Chemokine CCL5 Chemokine CXCL5 Chemokine CXCL5 Endometriosis Female Humans Inflammation Interleukin-6 Interleukin-6 RNA, Messenger RNA, Messenger Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha Vagina

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (24)

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