Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosis

Michael D. Mueller, Luca Mazzucchelli, Mazzucchelli L, Caroline Buri, Buri C, Dan I. Lebovic, Ekkehard Dreher, Dreher E, E. Dreher, Robert N. Taylor, Taylor RN
Fertility and sterility · 2003 · vol. 79 , pp. 815–820 · doi:10.1016/s0015-0282(02)04828-8 · PMID:12620496 · W2090555229
article OA: closed CC0 ⤵ 51 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Epithelial neutrophil-activating peptide 78 (ENA-78) levels were found to be significantly higher in the peritoneal fluid of women diagnosed with endometriosis compared to those without the condition.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate the presence of epithelial neutrophil-activating peptide 78 (ENA-78) in peritoneal fluid of women with and without endometriosis and to identify the cells that produce this inflammatory protein.DesignCase-control study.SettingUniversity hospital.Patient(s)Eighteen women with and 9 women without endometriosis.Main outcome measure(s)ENA-78 protein and mRNA levels were compared among women with and without endometriosis in samples of peritoneal fluid, samples of endometriotic lesions obtained by biopsy during laparoscopy, and peritoneal macrophages. Enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and in situ hybridization methods were used. Secretion of ENA-78 protein by interleukin-1beta-stimulated endometriotic stromal cells and in the media of lipopolysaccharide-stimulated peritoneal macrophages were compared to that in unstimulated cell cultures.Result(s)Peritoneal fluid concentrations of ENA-78 were significantly higher in affected women than in controls. Ectopic epithelial and stromal cells and peritoneal macrophages express ENA-78 messenger RNA. Interleukin-1beta stimulation of stromal cell cultures resulted in a 23-fold increase in ENA-78 concentration, and lipopolysaccharide stimulation of peritoneal macrophages increased concentrations by 8-fold.Conclusion(s)Levels of ENA-78 are elevated in the peritoneal fluid of women with endometriosis. Ectopic glandular cells, ectopic stromal cells, and peritoneal macrophages express this inflammatory chemokine. Epithelial neutrophil-activating peptide 78 may play an important role in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokines, CXC Endometriosis Interleukin-8 Interleukin-8 Ascitic Fluid Case-Control Studies Chemokine CXCL5 Endometriosis Female Humans In Situ Hybridization Interleukin-1 Interleukin-1 Interleukin-8 Interleukin-8 Lipopolysaccharides Lipopolysaccharides Macrophages, Peritoneal Macrophages, Peritoneal

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (50)

Source provenance

europepmc
last seen: 2026-09-10T06:15:44.054944+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:55.732728+00:00
unpaywall
last seen: 2026-09-10T06:36:06.991349+00:00
License: CC0 · commercial use OK