Increased granulocyte chemotactic protein‐2 concentrations in peritoneal fluid of women with endometriosis

Nobuhiro Suzumori, Xaio Xi Zhao, Kaoru Suzumori
Acta obstetricia et gynecologica Scandinavica · 2005 · vol. 84(12) , pp. 1141–1144 · doi:10.1111/j.0001-6349.2005.00680.x · PMID:16305697 · W2063859837
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This study found increased concentrations of granulocyte chemotactic protein-2 in the peritoneal fluid of women with endometriosis, particularly during the proliferative phase, with levels correlating to disease stage.

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Abstract

BACKGROUND: To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle. METHODS: Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay. RESULT: Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis. CONCLUSION: Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.

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Condition tags

endometriosis

MeSH descriptors

Chemokines, CXC Endometriosis Endometriosis Menstrual Cycle Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Chemokine CXCL6 Chemokines, CXC Chemotaxis, Leukocyte Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Granulocytes Humans Middle Aged Severity of Illness Index

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (5)

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