Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis

Nobuhiro Suzumori, Suzumori N, Xaio Xi Zhao, Zhao XX, Kaoru Suzumori, Suzumori K
Acta obstetricia et gynecologica Scandinavica · 2005 · vol. 84(12) , pp. 1141–1144 · doi:10.1111/j.0001-6349.2005.00680.x · PMID:16305697 · W2063859837
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This study found increased concentrations of granulocyte chemotactic protein-2 in the peritoneal fluid of women with endometriosis, particularly during the proliferative phase, with levels correlating to disease stage.

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Abstract

BACKGROUND: To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle. METHODS: Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay. RESULT: Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis. CONCLUSION: Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.

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Condition tags

endometriosis

MeSH descriptors

Chemokines, CXC Endometriosis Endometriosis Menstrual Cycle Menstrual Cycle Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Chemokine CXCL6 Chemokine CXCL6 Chemokines, CXC Chemokines, CXC Chemotaxis, Leukocyte Chemotaxis, Leukocyte Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (5)

Source provenance

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