Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis

Nobuhiro Suzumori, Suzumori N, Katano K, Kinue Katano, Kaoru Suzumori, Suzumori K
Fertility and Sterility · 2004 · vol. 81(2) , pp. 305–308 · doi:10.1016/j.fertnstert.2003.08.011 · PMID:14967364 · W2072396753
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the relationship between epithelial neutrophil-activating peptide-78 (ENA-78) levels in peritoneal fluid and the severity of endometriosis, finding a correlation between higher ENA-78 concentrations and more severe disease stages.

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Abstract

ObjectiveTo assess the release of epithelial neutrophil-activating peptide-78 (ENA-78) into peritoneal fluid in women with and without endometriosis.DesignRetrospective study.SettingNagoya City University Hospital.Patient(s)Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) and without (n = 24) endometriosis.Intervention(s)Peritoneal fluid samples were obtained at laparotomy or laparoscopy.Main outcome measure(s)The ENA-78 concentrations in the peritoneal fluid were measured using enzyme-linked immunosorbent assay (ELISA).Result(s)The concentrations of ENA-78 in the peritoneal fluid were markedly elevated in the endometriosis patients as compared with the controls, especially in women with severe stage disease.Conclusion(s)We conclude that ENA-78 is an important factor that may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokines, CXC Endometriosis Interleukin-8 Ascitic Fluid Biomarkers Biomarkers Chemokine CXCL5 Chemotaxis, Leukocyte Endometriosis Endometriosis Endometrium Endometrium Female Humans Interleukin-8 Interleukin-8 Neovascularization, Pathologic Neovascularization, Pathologic Reference Values

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (18)

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