Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis

Nobuhiro Suzumori, Suzumori N, Katano K, Kinue Katano, Kaoru Suzumori, Suzumori K
Fertility and sterility · 2004 · vol. 81(2) , pp. 305–308 · doi:10.1016/j.fertnstert.2003.08.011 · PMID:14967364 · W2072396753
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This study investigated the relationship between epithelial neutrophil-activating peptide-78 (ENA-78) levels in peritoneal fluid and the severity of endometriosis, finding a correlation between higher ENA-78 concentrations and more severe disease stages.

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Abstract

OBJECTIVE: To assess the release of epithelial neutrophil-activating peptide-78 (ENA-78) into peritoneal fluid in women with and without endometriosis. DESIGN: Retrospective study. SETTING: Nagoya City University Hospital. PATIENT(S): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) and without (n = 24) endometriosis. INTERVENTION(S): Peritoneal fluid samples were obtained at laparotomy or laparoscopy. MAIN OUTCOME MEASURE(S): The ENA-78 concentrations in the peritoneal fluid were measured using enzyme-linked immunosorbent assay (ELISA). RESULT(S): The concentrations of ENA-78 in the peritoneal fluid were markedly elevated in the endometriosis patients as compared with the controls, especially in women with severe stage disease. CONCLUSION(S): We conclude that ENA-78 is an important factor that may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokines, CXC Chemokines, CXC Endometriosis Interleukin-8 Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers Biomarkers Chemokine CXCL5 Chemokine CXCL5 Chemotaxis, Leukocyte Chemotaxis, Leukocyte Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (17)

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