Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion

Aydin Arici, Aydın Arıcı, Ioannis Matalliotakis, Anastasia Goumenou, Georgios Koumantakis, Simon Vassiliadis, Belgin Selam, Neal G Mahutte
Human Reproduction · 2003 · vol. 18(2) , pp. 429–432 · doi:10.1093/humrep/deg083 · PMID:12571184 · W2127317930
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Peritoneal fluid interleukin-15 concentrations were elevated in women with endometriosis compared to controls and inversely correlated with disease stage and invasion depth.

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Abstract

BACKGROUND: Interleukin (IL)-15 is a novel cytokine with immunoregulatory and angiogenic properties. We compared IL-15 levels in the peritoneal fluid (PF) of women with and without endometriosis. METHODS: PF samples were obtained from 55 women with endometriosis (23 with superficial peritoneal implants, 19 with deep endometriotic implants and 13 with ovarian endometriomas). Eighteen women with normal pelvic anatomy undergoing tubal sterilization served as controls. RESULTS: PF IL-15 concentrations were increased in women with endometriosis (2.7 +/- 0.5 pg/ml) versus controls (2.1 +/- 0.3 pg/ml; P < 0.001). However, IL-15 levels were higher in women with superficial peritoneal implants (2.9 +/- 0.5 pg/ml) than women with deep endometriotic implants (2.6 +/- 0.4 pg/ml; P = 0.01) or ovarian endometriomas (2.2 +/- 0.4 pg/ml; P < 0.001). IL-15 was also higher in women with deep implants than in those with endometriomas (P < 0.05). PF IL-15 correlated inversely with both depth of invasion (r = -0.52) and the stage of endometriosis (r = -0.42). PF IL-15 levels demonstrated little variation during the menstrual cycle, and did not discriminate between women with infertility or pelvic pain. CONCLUSION: PF IL-15 levels are increased in women with endometriosis. However, IL-15 levels are inversely correlated with the depth of invasion and disease stage, suggesting a possible role for this cytokine in the early pathogenesis of endometriosis.

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Condition tags

mesh:D004715mesh:D017699endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Interleukin-15 Adult Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Interleukin-15 Menstrual Cycle Osmolar Concentration Pelvic Pain Pelvic Pain Peritoneum

Citation neighborhood

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References (40)

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