Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis

Jong-Young Kwak, J. Kwak, Sang-Won Park, S.-W. Park, Ki-Hyung Kim, Ki Hyun Kim, Yong-Jin Na, Kyu-Sup Lee, Kwan-Soo Lee
Human Reproduction · 2002 · vol. 17(3) , pp. 595–600 · doi:10.1093/humrep/17.3.595 · PMID:11870109 · W2053506100
article OA: closed CC0 ⤵ 44 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Plasma and peritoneal fluid from advanced endometriosis patients significantly reduced neutrophil apoptosis in vitro, with interleukin-8 identified as a key factor in peritoneal fluid.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: The increased production of pro-inflammatory chemoattractant cytokines for neutrophils in endometriosis suggests that changes in the immune system play an important role in the pathophysiology of endometriosis. The effects of plasma and peritoneal fluid from patients with advanced endometriosis on the apoptosis of neutrophils were investigated. METHODS: Apoptotic changes of neutrophils were evaluated by morphological changes using Giemsa staining. Apoptosis was confirmed by DNA electrophoretic analysis. RESULTS: Compared with the plasma (n = 20) and peritoneal fluid (n = 5) of healthy controls, the addition of 10% plasma (n = 20) and peritoneal fluid (n = 10) from patients with endometriosis to an in-vitro culture of neutrophils from healthy subjects reduced the percentage of apoptotic cells from 65.3 +/- 6.6 to 27.2 +/- 4.6% (P < 0.001) and from 45.3 +/- 4.8 to 10.5 +/- 4.3% (P < 0.001) respectively. Neutralizing interleukin-8 antibody abrogated the delay of neutrophil apoptosis induced by peritoneal fluid, but not in the plasma of endometriosis patients. CONCLUSIONS: These findings show that interleukin-8 is one of the neutrophil survival factors in the peritoneal fluid of endometriosis patients and that an unidentified survival factor is also present in the plasma of patients with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Apoptosis Ascitic Fluid Blood Physiological Phenomena Endometriosis Neutrophils Adult Antibodies Antibodies Apoptosis Apoptosis Ascitic Fluid Cells, Cultured Dactinomycin Dactinomycin Endometriosis Female Humans Interleukin-8 Interleukin-8 Interleukin-8

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (44)

Source provenance

europepmc
last seen: 2026-06-17T06:13:18.893374+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:13.417725+00:00
unpaywall
last seen: 2026-06-17T06:32:23.968882+00:00
License: CC0 · commercial use OK