Endometriosis Impact on Fertility: A Review of Pathogenesis, Diagnosis and Treatment

Monzer Farah, Sara Mahmoud, Mohammed Osman, Amro Taha, Mohamed B. Hassan, K Tamai, T Koyama, T Saga, A Kido, M Kataoka, S Umeoka, . Togashi, K, B Smolarz, K Szyo, H Romanowicz, Y Moradi, M Shams-Beyranvand, S Khateri, S Gharahjeh, S Tehrani, F Varse, . Najmi, Z, J Sampson, C Scheerer, P Bauer, V Chiantera, J Sehouli, A Kaufmann, S Mechsner, W Zheng, N Li, J Wang, E Ulukus, M Ulukus, A Arici, S Liang, E Mok-Lin, A Wolfberg, H Hollinquist, M Laufer, R Parkar, W Kamau, L Konrad, R Dietze, P Kudipudi, F Horn, I Meinhold-Heerlein, J Troncon, A Zani, A Vieira, O Poli-Neto, A Nogueira, J Rosa-E-Silva, H Suginami, J Kwak, S Park, K Kim, Y Na, K Lee, L Schulke, M Berbic, F Manconi, N Tokushige, R Markham, I Fraser, B Selam, U Kayisli, J Garcia-Velasco, Y Lin, Y Chen, H Chang, H Au, C Tzeng, Y Huang, B Mckinnon, D Bertschi, N Bersinger, M Mueller, C Fox, S Morin, J Jeong, R Scott, B Lessey, P Vercellini, P Crosignani, E Somigliana, P Vigano, L Buggio, G Bolis, L Fedele, N Shigesi, M Kvaskoff, S Kirtley, Q Feng, H Fang, J Knight, . Becker, C, K May, S Conduit-Hulbert, J Villar, S Kennedy, C Becker, S Treloar, T O'connor, D O'connor, V Martin, N, R Saha, H Pettersson, P Svedberg, M Olovsson, A Bergqvist, L Marions, . Kuja-Halkola, R, P Koninckx, A Ussia, L Adamyan, A Wattiez, V Gomel, D Martin, M Ibrahim, M Sillem, J Plendl, C Exacoustos, D Luciano, B Corbett, G De Felice, M Di Feliciantonio, A Luciano, E Zupi, F Cousins, C Gargett, M Barcena De Arellano, J Gericke, U Reichelt, A Okuducu, A Ebert, . Mechsner, S, J Bartley, M Infanger, C Loddenkemper, J Herbel, H Nazri, M Imran, R Fischer, R Heilig, S Manek, R Dragovic, Asrm, D Guzick, N Silliman, G Adamson, V Buttram, M Canis, L Malinak, R Schenken, D Pasta, J Boujenah, C Bonneau, J Hugues, C Sifer, C Poncelet, D Olive, G Stohs, D Metzger, R Franklin, T Tanbo, P Fedorcsak, T D'hooghe, S Debrock, J Hill, C Meuleman, H Opien, A Polec, M Stensen, T byholm, K Holoch, E Oral, G Huszar, S Yoshida, T Harada, T Iwabe, F Taniguchi, M Mitsunari, N Yamauchi, . Terakawa, J Punnonen, K Teisala, H Ranta, B Bennett, R Punnonen, H Ota, S Igarashi, N Kato, T Tanaka, A Pellicer, N Oliveira, A Ruiz, J Remoh, C Simn, I Brosens, G Leyendecker, G Kunz, L Wildt, D Beil, H Deininger, X Santamaria, E Massasa, H Taylor, D Cahill, M Hull, S Bulun, Y Cheng, P Yin, G Imir, H Utsunomiya, E Attar, . Kim, J, A Sarapik, K Haller-Kikkatalo, M Utt, K Teesalu, A Salumets, R Uibo, K Zeitoun, K Osteen, N Keller, F Feltus, M Melner, E Hauzman, R Spaczynski, A Duleba, S Agarwal, C Chapron, L Giudice, N Leyland, S Missmer, . Taylor, H, A Hsu, I Khachikyan, P Stratton, J Donnez, L Marcellin, B Borghese, P Santulli, L Kuznetsov, K Dworzynski, M Davies, C Overton, H Riazi, N Tehranian, S Ziaei, E Mohammadi, E Hajizadeh, A Montazeri, A Fassbender, A Vodolazkaia, P Saunders, D Lebovic, E Waelkens, B De Moor, T & D'hooghe, V Nisenblat, P Bossuyt, R Shaikh, C Farquhar, V Jordan, C Scheffers, . Hull, M, P Acin, I Velasco, S Guo, J Wenger, P Petignat, R Marci, S Bianchi, R Raffaelli, A Portuese, M Abrao, M Gonalves, J Dias, S Podgaec, L Chamie, R Blasbalg, P Parasar, P Ozcan, K Terry, A Baldi, M Campioni, P Signorile, G Dunselman, N Vermeulen, C Calhaz-Jorge, B De Bie, . Nelen, W, B Eskenazi, M Warner, L Bonsignore, S Samuels, R Greb, . Saridogan, E, A Greene, S Lang, J Kendziorski, J Sroga-Rios, T Herzog, K Burns, J Brown, L Zhou, J Fu, D Liu, Q Wang, H Chen, S Yang, W Huang, N Johnson, L Hummelshoj, C Allaire, . Vercellini, P, T Jacobson, J Duffy, D Barlow, S Marcoux, R Maheux, S Brub, S Angioni, V Cela, F Sedda, E Stochino Loi, V Cofelice, A Pontis, G Melis, L Benschop, N Van Der Poel, M Heineman
In: Journal of Gynecology & Reproductive Medicine · 2022 · vol. 6(4) · doi:10.33140/jgrm.06.04.07 · W4318472319
review OA: diamond CC0
AI-generated summary by claude@2026-06, 2026-06-06

This review discusses theories on endometriosis-related infertility, noting surgical treatment improves fertility, while medical treatment does not, and assisted reproductive technologies can be used.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a common problem affecting 5-10% of women of childbearing age. It is a condition with unknown pathology, leaving us with several theories. However, about half of women with endometriosis complain of difficulty conceiving. The exact mechanism remains unclear. In severe cases, infertility is associated with anatomical disturbances, but the pathophysiology of infertility in mild cases of endometriosis is not understood. From the balance of available evidence, medical treatment of endometriosis does not improve fertility and should not be given to patients wishing to conceive. However, surgical ablation or excision of minimal and mild endometriosis does improve fertility chances. Methods of assisted reproductive technology can be used in combination with hormonal treatment in women with mild endometriosis. Endometriosis treatment is yet to be considered effective. This article is a review of the literature on endometriosis-a disease affecting the quality of life in women all over the globe.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (91)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK