Abnormal peritoneal regulation of chemokine activation—The role of IL‐8 in pathogenesis of endometriosis

Justyna Sikora, Marta Smycz-Kubańska, Marta Smycz‐Kubańska, Aleksandra Mielczarek-Palacz, Aleksandra Mielczarek‐Palacz, Zdzisława Kondera‐Anasz, Zdzisława Kondera-Anasz
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 77(4) · doi:10.1111/aji.12622 · PMID:28120482 · W2581250813
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This review details how elevated interleukin-8 in peritoneal fluid and serum correlates with endometriosis severity, promoting disease development through immune cell recruitment, angiogenesis, and ectopic endometrial cell proliferation.

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Abstract

PROBLEM: Endometriosis is a chronic inflammatory disease associated with an impairment in immune response. Disorders in the peritoneal fluid and ectopic endometrium macrophage populations and their secretory products create a specific microenvironment inducing the development of the disease. The important factors involved in inflammation associated with endometriosis are chemokines, especially interleukin (IL)-8. For this reason, the current study briefly reviews the role of IL-8 in the pathogenesis of endometriosis. METHOD OF STUDY: A systematic review was done on all published studies that compared IL-8 expression and concentration in patients with and without endometriosis to evaluate their potential as biomarkers for the disease. RESULTS: IL-8 induces chemotaxis of neutrophils and other immune cells; also, it is a potent angiogenic agent. Most researchers pointed to the increased peritoneal and serum IL-8 levels and showed correlation with the severity of the disease, size and number of the active lesions. IL-8 takes part in all processes during the development of the disease: adhesion, invasion, and implantation of ectopic tissue. Additionally, the chemokine plays a role in growth and maintenance of ectopic endometrial tissue directly affecting endometrial cell proliferation. IL-8 might also protect ectopic cells against death by apoptosis. CONCLUSION: It may act as an autocrine growth factor in the endometrium and promotes the vicious circle of endometrial cell attachment and, in consequence, may lead to a transformation from acute to chronic inflammation stage.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-8 Peritoneum Biomarkers Biomarkers Cellular Microenvironment Cellular Microenvironment Endometriosis Endometriosis Female Humans Interleukin-8 Interleukin-8 Peritoneum Peritoneum

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK