Reciprocal Communication Between Endometrial Stromal Cells and Macrophages

Kathleen M Eyster, Keith A Hansen, Emily Winterton, Olga Klinkova, Donis Drappeau, Donis D. Drappeau, Connie J Mark-Kappeler
Reproductive sciences (Thousand Oaks, Calif.) · 2010 · vol. 17(9) , pp. 809–822 · doi:10.1177/1933719110371854 · W2029263383
article OA: closed CC0 ⤵ 14 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Macrophages treated with endometrial stromal cell factors and endometrial stromal cells treated with macrophage factors showed differential gene expression, indicating reciprocal communication that may support endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study investigated whether reciprocal signaling occurs between cultured human endometrial stromal cells and macrophages, using a telomerase-immortalized human endometrial stromal cell line treated with macrophage-conditioned medium with or without estradiol and progesterone, and assessing macrophage responses to stromal-cell conditioned medium. DNA microarray revealed 716 differentially expressed genes in stromal cells after macrophage factors, including upregulation of IL-8/CXCL8, MMP3, CYR61, CTGF, and tenascin C with downregulation of integrin α-6, while 15 named genes changed in macrophages in response to stromal-cell factors. The authors’ key caveat is that the work relies on in vitro conditioned-medium and an immortalized stromal cell line, which may not fully capture in vivo cellular complexity. This paper is centrally about endometriosis — it tests macrophage–endometrial stromal reciprocal communication and proposes that the resulting gene expression changes could support endometriosis establishment.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715

MeSH descriptors

Endometriosis Endometrium Macrophages Paracrine Communication Paracrine Communication Paracrine Communication Stromal Cells Culture Media, Conditioned Culture Media, Conditioned Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Female Gene Expression Profiling Gene Expression Profiling

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

Cited by (14)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:07.008521+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK